PMID- 24520365
OWN - NLM
STAT- MEDLINE
DCOM- 20141013
LR  - 20220408
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - A school-based cross-sectional survey of adverse events following 
      co-administration of albendazole and praziquantel for preventive chemotherapy 
      against urogenital schistosomiasis and soil-transmitted helminthiasis in Kwale 
      County, Kenya.
PG  - e88315
LID - 10.1371/journal.pone.0088315 [doi]
LID - e88315
AB  - BACKGROUND: Soil-transmitted helminths and schistosomiasis are mostly prevalent 
      in developing countries due to poor sanitation and lack of adequate clean water. 
      School-age children tend to be the target of chemotherapy-based control 
      programmes because they carry the heaviest worm and egg burdens. The present 
      study examines adverse events (AEs) experienced following co-administration of 
      albendazole and praziquantel to school-age children in a rural area in Kwale 
      County, Kenya. METHODS: Children were treated with single doses of albendazole 
      and praziquantel tablets and then interviewed using a questionnaire for post 
      treatment AEs. RESULTS: Overall, 752 children, 47.6% boys, participated in the 
      study. Their median (interquartile range) age was 12.0 (10.0-14.0) years. A total 
      of 190 (25.3%) children reportedly experienced at least one AE. In total, 239 
      cases of AEs were reported with the most frequent being abdominal pains (46.3%), 
      dizziness (33.2%) and nausea (21.1%). Majority of the reported AEs (80.8%) 
      resolved themselves while 12.1% and 6.3% were countered by, respectively, 
      self-medication and visiting a nearby health facility. More girls (60.5%) than 
      boys (39.5%) reported AEs (P = 0.027). CONCLUSIONS: The AEs were mild and 
      transient, and were no worse than those expected following monotherapy. The 
      current study adds to the evidence base that dual administration of albendazole 
      and praziquantel in school-based mass drug administration is safe with only mild 
      adverse events noted.
FAU - Njenga, Sammy M
AU  - Njenga SM
AD  - Eastern and Southern Africa Centre of International Parasite Control (ESACIPAC), 
      Kenya Medical Research Institute (KEMRI), Mbagathi Road, Nairobi, Kenya.
FAU - Ng'ang'a, Paul M
AU  - Ng'ang'a PM
AD  - Division of Vector-Borne Diseases & Neglected Tropical Diseases (DVBD-NTD), 
      Ministry of Health, Nairobi, Kenya.
FAU - Mwanje, Mariam T
AU  - Mwanje MT
AD  - Division of Vector-Borne Diseases & Neglected Tropical Diseases (DVBD-NTD), 
      Ministry of Health, Nairobi, Kenya.
FAU - Bendera, Fatuma S
AU  - Bendera FS
AD  - Environmental Health Department, Kwale County, Kenya.
FAU - Bockarie, Moses J
AU  - Bockarie MJ
AD  - Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
LA  - eng
GR  - G1001337/MRC_/Medical Research Council/United Kingdom
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140210
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Anthelmintics)
RN  - 0 (Soil)
RN  - 6490C9U457 (Praziquantel)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Adolescent
MH  - Albendazole/administration & dosage/adverse effects/*therapeutic use
MH  - Anthelmintics/administration & dosage/therapeutic use
MH  - Child
MH  - Cross-Sectional Studies
MH  - Drug Therapy
MH  - Drug Therapy, Combination
MH  - Female
MH  - *Health Surveys
MH  - Helminthiasis/*drug therapy/epidemiology/prevention & control
MH  - Humans
MH  - Kenya/epidemiology
MH  - Male
MH  - Praziquantel/administration & dosage/adverse effects/*therapeutic use
MH  - Schistosomiasis haematobia/*drug therapy/epidemiology/prevention & control
MH  - *Schools
MH  - Soil/*parasitology
PMC - PMC3919734
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/02/13 06:00
MHDA- 2014/10/14 06:00
PMCR- 2014/02/10
CRDT- 2014/02/13 06:00
PHST- 2013/08/14 00:00 [received]
PHST- 2014/01/06 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/10/14 06:00 [medline]
PHST- 2014/02/10 00:00 [pmc-release]
AID - PONE-D-13-34994 [pii]
AID - 10.1371/journal.pone.0088315 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 10;9(2):e88315. doi: 10.1371/journal.pone.0088315. eCollection 
      2014.