PMID- 24520939
OWN - NLM
STAT- MEDLINE
DCOM- 20141228
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 18
IP  - 5
DP  - 2014 May
TI  - Association of GCK -30G> a polymorphism with gestational diabetes mellitus and 
      type 2 diabetes mellitus risk: a meta-analysis involving 18 case-control studies.
PG  - 289-98
LID - 10.1089/gtmb.2013.0427 [doi]
AB  - OBJECTIVE: Several studies have examined the association between the GCK -30G>A 
      polymorphism and the risk of gestational diabetes mellitus (GDM) and type 2 
      diabetes mellitus (T2DM). However, inferences from these studies are hindered by 
      their limited statistical power and conflicting results. The aim of this 
      meta-analysis is to provide a relatively comprehensive picture of the association 
      of the GCK -30G>A polymorphism with GDM and T2DM risk. METHODS: A literature 
      search for eligible studies published before August 15, 2013, was conducted in 
      PubMed, Embase, Web of Science, Cochrane Library, and CNKI (China National 
      Knowledge Infrastructure). Pooled odds ratios with their corresponding 95% 
      confidence intervals were used to evaluate the strength of the association under 
      a fixed- or random-effect model according to heterogeneity test results. All 
      analyses were performed using Stata software, version 12.0. RESULTS: Eighteen 
      case-control studies from 17 published reports were included in this 
      meta-analysis with a total of 2011 patients with GDM, 11,057 with T2DM, and 
      26,102 healthy controls. For GDM, the combined results showed that the risk 
      allele of the -30G>A polymorphism may be associated with an increased risk of 
      GDM. Stratified analyses showed that the magnitude of the effect was especially 
      significant among whites, indicating ethnicity differences for GDM 
      susceptibility. For T2DM, the pooled ORs were not significant in the overall 
      population, although all the ORs >1 suggested an increased risk of T2DM for 
      carriers of the A allele. However, whites seem to be significantly more 
      susceptible to T2DM than Asians. CONCLUSION: This meta-analysis indicated that 
      the risk allele of the GCK -30G>A polymorphism may increase GDM and T2DM risk in 
      whites, whereas additional studies are needed to confirm the effect of this 
      polymorphism on both diseases in Asians and Africans.
FAU - Yang, Sheng
AU  - Yang S
AD  - Department of Endocrinology, Shengjing Hospital of China Medical University , 
      Shenyang, China .
FAU - Du, Qiang
AU  - Du Q
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20140212
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - EC 2.7.1.2 (Glucokinase)
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Diabetes, Gestational/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Glucokinase/*genetics
MH  - Humans
MH  - Pregnancy
MH  - Risk Factors
EDAT- 2014/02/14 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/02/14 06:00
PHST- 2014/02/14 06:00 [entrez]
PHST- 2014/02/14 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - 10.1089/gtmb.2013.0427 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2014 May;18(5):289-98. doi: 10.1089/gtmb.2013.0427. 
      Epub 2014 Feb 12.