PMID- 24521762
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 78
IP  - 4
DP  - 2014
TI  - Prognostic value of late gadolinium enhancement on cardiac magnetic resonance 
      imaging in Japanese hypertrophic cardiomyopathy patients.
PG  - 929-37
AB  - BACKGROUND:  The prognostic value of late gadolinium enhancement (LGE) on 
      contrast-enhanced cardiovascular magnetic resonance (CMR) in Japanese 
      hypertrophic cardiomyopathy (HCM) patients in a large, single-center cohort was 
      investigated. METHODS AND RESULTS:  A total of 345 HCM patients (mean age, 59+/-17 
      years; 214 male) underwent CMR with gadolinium enhancement, and were followed 
      (mean duration, 21.8 months) for cardiovascular events. Patients were divided 
      into event-positive and event-negative groups. The clinical and CMR 
      characteristics were compared between the 2 groups, and predictors of 
      cardiovascular events assessed on multivariate analysis. LGE was positive in 252 
      patients (73%). The annual cardiovascular events rate was significantly higher in 
      patients with LGE than in those without (6.2%/year vs. 0.6%/year, P=0.003). On 
      multivariate analysis, LGE (hazard ratio [HR], 7.436; 95% confidence interval 
      [CI]: 1.001-55.228, P=0.050), increased myocardial mass index (HR, 1.013; 95% CI: 
      1.002-1.023, P=0.018), reduced left ventricular ejection fraction (HR, 0.965; 95% 
      CI: 0.945-0.985, P=0.001), and atrial fibrillation (HR, 2.257; 95% CI: 
      1.024-4.976, P=0.043) were significantly associated with cardiovascular events. 
      CONCLUSIONS:  The presence of LGE, increased myocardial mass index, reduced left 
      ventricular ejection fraction and atrial fibrillation were independent predictors 
      of adverse prognosis in Japanese HCM patients.  
FAU - Hen, Yasuki
AU  - Hen Y
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Iguchi, Nobuo
AU  - Iguchi N
FAU - Utanohara, Yuko
AU  - Utanohara Y
FAU - Takada, Kaori
AU  - Takada K
FAU - Machida, Haruhiko
AU  - Machida H
FAU - Takayama, Morimasa
AU  - Takayama M
FAU - Sumiyoshi, Tetsuya
AU  - Sumiyoshi T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140213
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Atrial Fibrillation/diagnostic imaging/physiopathology
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*physiopathology
MH  - Contrast Media/*administration & dosage
MH  - Follow-Up Studies
MH  - Gadolinium/*administration & dosage
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Radiography
MH  - Retrospective Studies
MH  - *Stroke Volume
EDAT- 2014/02/14 06:00
MHDA- 2014/10/21 06:00
CRDT- 2014/02/14 06:00
PHST- 2014/02/14 06:00 [entrez]
PHST- 2014/02/14 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - DN/JST.JSTAGE/circj/CJ-13-0979 [pii]
AID - 10.1253/circj.cj-13-0979 [doi]
PST - ppublish
SO  - Circ J. 2014;78(4):929-37. doi: 10.1253/circj.cj-13-0979. Epub 2014 Feb 13.