PMID- 24522481
OWN - NLM
STAT- MEDLINE
DCOM- 20150904
LR  - 20211021
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 34
IP  - 1
DP  - 2015 Jan
TI  - The long-term efficacy and tolerability of hyaluronic acid in adult patients with 
      Kashin-Beck disease of the knee.
PG  - 151-6
LID - 10.1007/s10067-014-2519-0 [doi]
AB  - The aim of this study was to prospectively evaluate the long-term efficacy and 
      tolerability of hyaluronic acid (HA) for the treatment of knee pain due to 
      Kashin-Beck disease (KBD). A total of 113 patients with KBD-based knee pain were 
      treated with a 3-week course of HA. Clinical assessments were performed for each 
      patient at 0 (baseline), 1, 2, 4, 8, 12, 24, and 52 weeks. The primary efficacy 
      measure was the visual analog scale (VAS) pain score. The secondary efficacy 
      measures included the WOMAC A (pain), B (stiffness), and C (function) scores; the 
      total WOMAC score; and the global assessments by patients and physicians. 
      Tolerability was evaluated based on adverse events (AEs) and physician reporting. 
      The VAS was significantly reduced within the first 4 weeks of treatment, and the 
      reduction was maintained over 52 weeks (p < 0.001 at each endpoint). These data 
      were supported by the secondary variables WOMAC A (all p < 0.001), WOMAC B 
      (p = 0.002, 0.003, and 0.019, respectively), WOMAC C (all p < 0.001), total WOMAC 
      (all p < 0.001), and the global assessments by patients and physicians at weeks 
      12, 24, and 52. No serious AEs were reported, and the overall incidence of AEs 
      was 10.6 %. This study suggests that the intra-articular injection of HA is 
      effective and well tolerated for the treatment of knee pain due to KBD as HA 
      therapy resulted in an improvement of symptoms for at least 52 weeks. Additional 
      randomized double-blind studies are needed to confirm our findings.
FAU - Tang, Xin
AU  - Tang X
AD  - Department of Orthopaedic Surgery, West China Hospital of Sichuan University, No. 
      37, Guoxue Alley, Chengdu, 610041, People's Republic of China.
FAU - Zhou, Zong-Ke
AU  - Zhou ZK
FAU - Liu, Gang
AU  - Liu G
FAU - Shen, Bin
AU  - Shen B
FAU - Kang, Peng-De
AU  - Kang PD
FAU - Li, Jian
AU  - Li J
FAU - Li, Qi
AU  - Li Q
FAU - Pei, Fu-Xing
AU  - Pei FX
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140213
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/administration & dosage/adverse effects/*therapeutic use
MH  - Injections, Intra-Articular
MH  - Kashin-Beck Disease/*drug therapy/pathology
MH  - Knee Joint/*drug effects/pathology
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2014/02/14 06:00
MHDA- 2015/09/05 06:00
CRDT- 2014/02/14 06:00
PHST- 2013/07/03 00:00 [received]
PHST- 2014/01/28 00:00 [accepted]
PHST- 2013/11/03 00:00 [revised]
PHST- 2014/02/14 06:00 [entrez]
PHST- 2014/02/14 06:00 [pubmed]
PHST- 2015/09/05 06:00 [medline]
AID - 10.1007/s10067-014-2519-0 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2015 Jan;34(1):151-6. doi: 10.1007/s10067-014-2519-0. Epub 2014 
      Feb 13.