PMID- 24523760
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140213
LR  - 20211021
IS  - 1735-0328 (Print)
IS  - 1726-6890 (Electronic)
IS  - 1726-6882 (Linking)
VI  - 12
IP  - 4
DP  - 2013 Fall
TI  - Cytotoxic, antioxidant and antimicrobial activities and phenolic contents of 
      eleven salvia species from iran.
PG  - 801-10
AB  - The plants of the genus Salvia synthesize several types of secondary metabolites 
      with antimicrobial, cytotoxic, and radical scavenging activities and are used in 
      the folk medicine of different countries. Eleven Salvia species including S. 
      aegyptiaca, S. aethiopis, S. atropatana, S. eremophila, S. hypoleuca, S. limbata, 
      S. nemorosa, S. santolinifolia, S. sclarea, S. syriaca, and S. xanthocheila were 
      collected from different localities in Iran and screened for their cytotoxic 
      activity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) 
      colorimetric assay. The antioxidant potential and total phenol contents of the 
      plant extracts were assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical 
      scavenging assay and Folin- Ciocalteu reagent respectively and finally 
      antimicrobial activity of the above extracts were determined by using agar disc 
      diffusion (ADD) and nutrient broth micro-dilution (NBMD) bioassays. Cytotoxic 
      activity of methanol, 80% methanol and dichloromethane extracts of these plants 
      were assessed on 3 human cancer cell lines. All of the extracts of S. eremophila 
      and S. santolinifolia were active at IC50 values of 10.5-75.2 mug extract/mL, 
      while the methanol and dichloromethane extracts of S. limbata, S. hypoleuca and 
      S. aethiopis showed considerable cytotoxic activity against the tested cell 
      lines. Among the tested plants for their antioxidant activity, S. nemorosa, S. 
      atropatana, S. santolinifolia, and S. eremophila were the most active radical 
      scavengers with higher total phenol contents while, S. limbata, S. xanthocheila 
      and S. aegyptiaca were the weakest ones. The methanol extracts of S. 
      santolinifolia, S. eremophila, S. sclarea and S. limbata inhibited the growth of 
      all tested bacterial strains.
FAU - Firuzi, Omidreza
AU  - Firuzi O
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Miri, Ramin
AU  - Miri R
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Asadollahi, Mojtaba
AU  - Asadollahi M
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Eslami, Saba
AU  - Eslami S
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Jassbi, Amir Reza
AU  - Jassbi AR
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC3920696
OTO - NOTNLM
OT  - Antibacterial activity
OT  - Cytotoxic activity
OT  - DPPH
OT  - Phenolics
OT  - Radical-scavenging
OT  - Salvia
EDAT- 2014/02/14 06:00
MHDA- 2014/02/14 06:01
PMCR- 2013/09/01
CRDT- 2014/02/14 06:00
PHST- 2014/02/14 06:00 [entrez]
PHST- 2014/02/14 06:00 [pubmed]
PHST- 2014/02/14 06:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - ijpr-12-801 [pii]
PST - ppublish
SO  - Iran J Pharm Res. 2013 Fall;12(4):801-10.