PMID- 24523822
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140213
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2014
DP  - 2014
TI  - Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like 
      Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 beta 
      -CREB Signaling Pathway.
PG  - 506735
LID - 10.1155/2014/506735 [doi]
LID - 506735
AB  - This study aimed to explore the antidepressant mechanisms of ginseng total 
      saponins (GTS) in the corticosterone-induced mouse depression model. In 
      Experiment 1, GTS (50, 25, and 12.5 mg kg(-1) d(-1), intragastrically) were given 
      for 3 weeks. In Experiment 2, the same doses of GTS were administrated after each 
      corticosterone (20 mg kg(-1) d(-1), subcutaneously) injection for 22 days. In 
      both experiments, mice underwent a forced swimming test and a tail suspension 
      test on day 20 and day 21, respectively, and were sacrificed on day 22. Results 
      of Experiment 1 revealed that GTS (50 and 25 mg kg(-1) d(-1)) exhibited 
      antidepressant activity and not statistically altered hippocampal protein levels 
      of brain-derived neurotrophic factor (BDNF) and neurofilament light chain (NF-L). 
      Results of Experiment 2 showed that GTS (50 and 25 mg kg(-1) d(-1)) ameliorated 
      depression-like behavior without normalizing hypercortisolism. The GTS treatments 
      reversed the corticosterone-induced changes in mRNA levels of BDNF and NF-L, and 
      protein levels of BDNF NF-L, phosphor-cAMP response element-binding protein 
      (Ser133), and phosphor-glycogen synthase kinase-3 beta (Ser9) in the hippocampus. 
      These findings imply that the effect of GTS on corticosterone-induced 
      depression-like behavior may be mediated partly through interfering with 
      hippocampal GSK-3 beta -CREB signaling pathway and reversing decrease of some 
      plasticity-related proteins.
FAU - Chen, Lin
AU  - Chen L
AD  - Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, 
      China.
FAU - Dai, Jianguo
AU  - Dai J
AD  - Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, 
      China.
FAU - Wang, Zhongli
AU  - Wang Z
AD  - Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, 
      China.
FAU - Zhang, Huiyu
AU  - Zhang H
AD  - Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, 
      China.
FAU - Huang, Yufang
AU  - Huang Y
AD  - Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, 
      China ; Laboratory of Pathological Sciences, Basic Medical College, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China.
FAU - Zhao, Yunan
AU  - Zhao Y
AD  - Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, 
      China ; Key Laboratory of Brain Research, Basic Medical College, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China.
LA  - eng
PT  - Journal Article
DEP - 20140109
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3913067
EDAT- 2014/02/14 06:00
MHDA- 2014/02/14 06:01
PMCR- 2014/01/09
CRDT- 2014/02/14 06:00
PHST- 2013/09/28 00:00 [received]
PHST- 2013/11/30 00:00 [revised]
PHST- 2013/12/05 00:00 [accepted]
PHST- 2014/02/14 06:00 [entrez]
PHST- 2014/02/14 06:00 [pubmed]
PHST- 2014/02/14 06:01 [medline]
PHST- 2014/01/09 00:00 [pmc-release]
AID - 10.1155/2014/506735 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2014;2014:506735. doi: 10.1155/2014/506735. 
      Epub 2014 Jan 9.