PMID- 24524285
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140217
LR  - 20220316
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 6
IP  - 1
DP  - 2014 Feb 13
TI  - Brain-derived neurotrophic factor, but not body weight, correlated with a 
      reduction in depression scale scores in men with metabolic syndrome: a 
      prospective weight-reduction study.
PG  - 18
LID - 10.1186/1758-5996-6-18 [doi]
AB  - BACKGROUND: Obesity, a critical component of metabolic syndrome (MetS), is 
      associated with depression. Deficiency of brain-derived neurotrophic factor 
      (BDNF) is involved in the mechanism of depression. We hypothesized that weight 
      reduction would improve depressive symptoms via increasing BDNF levels in obese 
      men. METHODS: Male adults with obesity were enrolled in a weight-reduction 
      program for twelve weeks. All subjects underwent daily caloric restriction and an 
      exercise program which was regularly assessed in group classes. Fasting blood 
      samples and Zung Self-Rating Depression Scale (Zung SDS) scores were collected 
      for assessments before and after the study. RESULTS: A total of 36 subjects 
      completed this program. The average reduction in body weight was 8.4 +/- 5.1 kg 
      (8.8 +/- 5.1%, P < 0.001). Fasting serum BDNF significantly increased after the 
      study (from 40.4 +/- 7.8 to 46.9 +/- 8.9 ng/ml, P < 0.001). However, the depression 
      symptoms, as assessed by the Zung Self-Rating Depression Scale (Zung SDS), did 
      not reduce significantly (P = 0.486). Divided into subgroups based on changes in 
      BDNF, Zung SDS scores were significantly reduced in subjects with greater BDNF 
      increase than in those with minor BDNF change (-3.9 +/- 6.2 vs. 2.3 +/- 6.7, 
      P = 0.009). The increased percentage of BDNF was inversely correlated with the 
      change in Zung SDS (r = -0.380, P = 0.022). Multivariate regression analysis 
      showed that reduction in BDNF was independently associated with change in Zung 
      SDS (95% confidence interval -0.315 to -0.052, P = 0.008). CONCLUSION: Zung SDS 
      only significantly improved in men with increased fasting BDNF levels after a 
      lifestyle intervention. TRIAL REGISTRATION: (NCT01065753, ClinicalTrials.gov).
FAU - Lee, I-Te
AU  - Lee IT
FAU - Fu, Chia-Po
AU  - Fu CP
FAU - Lee, Wen-Jane
AU  - Lee WJ
FAU - Liang, Kae-Woei
AU  - Liang KW
FAU - Lin, Shih-Yi
AU  - Lin SY
FAU - Wan, Chu-Jen
AU  - Wan CJ
FAU - Sheu, Wayne Huey-Herng
AU  - Sheu WH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, No, 1650, Section 4, Taiwan Boulevard, 
      Taichung 40705, Taiwan. whhsheu@vghtc.gov.tw.
LA  - eng
SI  - ClinicalTrials.gov/NCT01065753
PT  - Journal Article
DEP - 20140213
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC3925444
EDAT- 2014/02/15 06:00
MHDA- 2014/02/15 06:01
PMCR- 2014/02/13
CRDT- 2014/02/15 06:00
PHST- 2013/07/30 00:00 [received]
PHST- 2014/02/11 00:00 [accepted]
PHST- 2014/02/15 06:00 [entrez]
PHST- 2014/02/15 06:00 [pubmed]
PHST- 2014/02/15 06:01 [medline]
PHST- 2014/02/13 00:00 [pmc-release]
AID - 1758-5996-6-18 [pii]
AID - 10.1186/1758-5996-6-18 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2014 Feb 13;6(1):18. doi: 10.1186/1758-5996-6-18.