PMID- 24525099
OWN - NLM
STAT- MEDLINE
DCOM- 20150205
LR  - 20211203
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 66
DP  - 2014 Apr
TI  - Immunosuppressive effects of fisetin against dinitrofluorobenzene-induced atopic 
      dermatitis-like symptoms in NC/Nga mice.
PG  - 341-9
LID - S0278-6915(14)00082-9 [pii]
LID - 10.1016/j.fct.2014.01.057 [doi]
AB  - Atopic dermatitis (AD) is a multifactorial chronic skin disorder that is 
      increasing in prevalence globally. In NC/Nga mice, repetitive epicutaneous 
      applications of 2-4-dinitrofluorobenzene (DNFB) induces AD-like clinical 
      symptoms. Bioflanonol fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary 
      component found in plants, fruits and vegetables. Fisetin has various 
      physiological effects that include anti-oxidation, anti-angiogenesis, 
      anti-carcinogenesis and anti-inflammation. In this study, we investigated whether 
      fisetin relieves AD-like clinical symptoms induced by repeated DNFB treatment in 
      NC/Nga mice. Fisetin significantly inhibited infiltration of inflammatory cells 
      including eosinophils, mast cells and CD4(+) T and CD8(+) T cells, and suppressed 
      the expressions of cytokines and chemokines associated with dermal infiltrates in 
      AD-like skin lesions. Total serum immunoglobulin E (IgE) levels and the ratio of 
      phospho-NF-kappaB p65 to total NF-kappaB p65 were markedly reduced by fisetin. Fisetin 
      also reduced the production of interferon-gamma and interleukin-4 by activated 
      CD4(+) T cells in a dose-dependent manner, whereas the anti-inflammatory 
      cytokine, interleukin-10 was increased. These results implicate fisetin as a 
      potential therapeutic for AD.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Kim, Gun-Dong
AU  - Kim GD
AD  - Department of Microbiology, School of Medicine, Kyung Hee University, Seoul 
      130-701, Republic of Korea.
FAU - Lee, Seung Eun
AU  - Lee SE
AD  - Department of Microbiology, School of Medicine, Kyung Hee University, Seoul 
      130-701, Republic of Korea.
FAU - Park, Yong Seek
AU  - Park YS
AD  - Department of Microbiology, School of Medicine, Kyung Hee University, Seoul 
      130-701, Republic of Korea.
FAU - Shin, Dong-Hoon
AU  - Shin DH
AD  - Department of Food & Biotechnology, College of Life Science, Korea University, 
      Seoul 136-701, Republic of Korea.
FAU - Park, Gwi Gun
AU  - Park GG
AD  - Department of Food Science & Biotechnology, College of Life Science, Gachon 
      University, Seongnam 461-701, Republic of Korea.
FAU - Park, Cheung-Seog
AU  - Park CS
AD  - Department of Microbiology, School of Medicine, Kyung Hee University, Seoul 
      130-701, Republic of Korea. Electronic address: pcs@khu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20140210
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (DNA Primers)
RN  - 0 (Flavonoids)
RN  - 0 (Flavonols)
RN  - 0 (Immunosuppressive Agents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - D241E059U6 (Dinitrofluorobenzene)
RN  - OO2ABO9578 (fisetin)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - CD4-Positive T-Lymphocytes/metabolism
MH  - DNA Primers
MH  - Dermatitis, Atopic/*etiology
MH  - Dinitrofluorobenzene/*toxicity
MH  - Flavonoids/*pharmacology
MH  - Flavonols
MH  - Immunoglobulin E/blood
MH  - Immunosuppressive Agents/*pharmacology
MH  - Male
MH  - Mice
MH  - Polymerase Chain Reaction
OTO - NOTNLM
OT  - 2-4-Dinitrofluorobenzene
OT  - Atopic dermatitis
OT  - Fisetin
OT  - NC/Nga
OT  - NF-kappaB
EDAT- 2014/02/15 06:00
MHDA- 2015/02/06 06:00
CRDT- 2014/02/15 06:00
PHST- 2013/11/01 00:00 [received]
PHST- 2014/01/14 00:00 [revised]
PHST- 2014/01/31 00:00 [accepted]
PHST- 2014/02/15 06:00 [entrez]
PHST- 2014/02/15 06:00 [pubmed]
PHST- 2015/02/06 06:00 [medline]
AID - S0278-6915(14)00082-9 [pii]
AID - 10.1016/j.fct.2014.01.057 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2014 Apr;66:341-9. doi: 10.1016/j.fct.2014.01.057. Epub 2014 
      Feb 10.