PMID- 2452537
OWN - NLM
STAT- MEDLINE
DCOM- 19880609
LR  - 20200716
IS  - 0372-9311 (Print)
IS  - 0372-9311 (Linking)
IP  - 2
DP  - 1988 Feb
TI  - [Immunomodulating activity of RNA mononucleotides].
PG  - 58-63
AB  - The immunological action of RNA mononucleotides was studied in animal 
      experiments. The most pronounced activation of macrophagal glycolysis urea cycle, 
      oxidative phosphorylation, lysosomal hydrolases was induced by uridine 
      5'-monophosphate (5'-UMP) and guanosine 5'-monophosphate (5'-GMP); 5'-GMP also 
      induced the maximum increase of the expression of FC gamma receptors. 5'-UMP 
      ensured cell activation comparable with the total action of all mononucleotides. 
      5'-UMP and 5'-GMP, used in combination, produced the highest stimulating effect 
      on macrophages, and the addition of low-active adenosine 5'-monophosphate 
      (5'-AMP) to active 5'-UMP did not decrease the stimulating potency of the latter. 
      The stimulating activity of sodium nucleinate exceeded that of all 
      mononucleotides and their combinations. 5'-GMP and 5'-AMP induced the maximum 
      activation of oxygen metabolism, evaluated by chemiluminescence, while 5'-UMP and 
      cytidine 5'-monophosphate (5'CMP) proved to be inactive. The shift of the 
      phosphate group to the third carbon atom or the production of the oligonucleotide 
      5'-UMP consisting of 5-15 nucleotides resulted in the appearance of the capacity 
      for stimulating oxygen metabolism in macrophages. Their in vitro cultivation with 
      5'-GMP and 5'-AMP induced the maximum increase of cell spreading in comparison 
      with other mononucleotides, while the maximum increase of phagocytosis was 
      ensured only by 5'-UMP and 5'-GMP.2+ 5'-UMP and 5'-GMP enhanced nonospecific 
      resistance to Salmonella typhi infection, and sodium nucleinate, to Pseudomonas 
      pseudomallei and Pseudomonas mallei infections.
FAU - Zemskov, V M
AU  - Zemskov VM
FAU - Rodionov, S V
AU  - Rodionov SV
FAU - Khramtsov, A V
AU  - Khramtsov AV
FAU - Barsukov, A A
AU  - Barsukov AA
FAU - Pantin, V I
AU  - Pantin VI
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Immunomoduliruiushchaia aktivnost' mononukleotidov RNK.
PL  - Russia (Federation)
TA  - Zh Mikrobiol Epidemiol Immunobiol
JT  - Zhurnal mikrobiologii, epidemiologii i immunobiologii
JID - 0415217
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Nucleotides)
RN  - 0 (Receptors, Fc)
RN  - 415SHH325A (Adenosine Monophosphate)
RN  - 63231-63-0 (RNA)
RN  - 85-32-5 (Guanosine Monophosphate)
RN  - E2OU15WN0N (Uridine Monophosphate)
RN  - F469818O25 (Cytidine Monophosphate)
SB  - IM
MH  - Adenosine Monophosphate/pharmacology
MH  - *Adjuvants, Immunologic
MH  - Animals
MH  - Cricetinae
MH  - Cytidine Monophosphate/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Guanosine Monophosphate/pharmacology
MH  - Immunization
MH  - Luminescent Measurements
MH  - Macrophages/drug effects/enzymology/immunology
MH  - Melioidosis/immunology
MH  - Mesocricetus
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Nucleotides/*pharmacology
MH  - Phagocytosis/drug effects
MH  - RNA/*pharmacology
MH  - Receptors, Fc/drug effects/immunology
MH  - Structure-Activity Relationship
MH  - Typhoid Fever/immunology
MH  - Uridine Monophosphate/pharmacology
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
PST - ppublish
SO  - Zh Mikrobiol Epidemiol Immunobiol. 1988 Feb;(2):58-63.