PMID- 24525704
OWN - NLM
STAT- MEDLINE
DCOM- 20140527
LR  - 20140409
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 163
IP  - 3
DP  - 2014
TI  - Decreased levels of lipoxin A4 and annexin A1 in wheezy infants.
PG  - 193-7
LID - 10.1159/000358490 [doi]
AB  - OBJECTIVE: Wheezing is a common and challenging health issue in infancy and early 
      childhood. Asthma diagnosis is frequent in patients with a history of recurrent 
      wheezing. A relationship has been reported between asthma and anti-inflammatory 
      mediators such as lipoxin A4 and annexin A1. However, this remains uncertain in 
      wheezy infants. The aim of the present study was to determine lipoxin A4 and 
      annexin A1 levels in wheezy infants. MATERIALS AND METHODS: Eighty-seven patients 
      aged 6-36 months were included in this study. Demographic characteristics, 
      clinical features, laboratory data, clinical diagnoses, and treatments, if 
      present, were recorded. Patients were divided into 2 groups: patients with 
      wheezing (n = 59) and healthy controls (n = 28). Blood samples were taken and 
      lipoxin A4 and annexin A1 levels were evaluated by ELISA. RESULTS: Lipoxin A4 and 
      annexin A1 levels were significantly lower in the wheezing group than in the 
      control group (p < 0.05). A significant correlation was found between the serum 
      total immunoglobulin E (IgE) level and the percentage and absolute number of 
      eosinophils (p < 0.05). No significant correlation was found in terms of lipoxin 
      A4 and annexin A1 levels, the serum total IgE level, and the percentage and 
      absolute number of eosinophils among groups (p > 0.05). CONCLUSION: This is the 
      first study to assess lipoxin A4 and annexin A1 levels in wheezy infants. The 
      levels of lipoxin A4 and annexin A1 were found to be low in wheezy infants. We 
      hope that these results will lead to novel therapeutic options for asthma in 
      cases where an optimal treatment modality is lacking.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Eke Gungor, Hatice
AU  - Eke Gungor H
AD  - Department of Pediatric Allergy, Erciyes University School of Medicine, Kayseri, 
      Turkey.
FAU - Tahan, Fulya
AU  - Tahan F
FAU - Gokahmetoglu, Selma
AU  - Gokahmetoglu S
FAU - Saraymen, Berkay
AU  - Saraymen B
LA  - eng
PT  - Journal Article
DEP - 20140213
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Annexin A1)
RN  - 0 (Lipoxins)
RN  - 0 (lipoxin A4)
SB  - IM
MH  - Annexin A1/*blood
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Infant
MH  - Lipoxins/*blood
MH  - Male
MH  - Respiratory Sounds/*immunology
EDAT- 2014/02/15 06:00
MHDA- 2014/05/28 06:00
CRDT- 2014/02/15 06:00
PHST- 2013/09/11 00:00 [received]
PHST- 2014/01/08 00:00 [accepted]
PHST- 2014/02/15 06:00 [entrez]
PHST- 2014/02/15 06:00 [pubmed]
PHST- 2014/05/28 06:00 [medline]
AID - 000358490 [pii]
AID - 10.1159/000358490 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2014;163(3):193-7. doi: 10.1159/000358490. Epub 2014 
      Feb 13.