PMID- 24526290
OWN - NLM
STAT- MEDLINE
DCOM- 20150303
LR  - 20211021
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 37
IP  - 4
DP  - 2014 Aug
TI  - High-intensity swimming exercise increases dust mite extract and 
      1-chloro-2,4-dinitrobenzene-derived atopic dermatitis in BALB/c mice.
PG  - 1179-85
LID - 10.1007/s10753-014-9843-z [doi]
AB  - The aim of this study was to investigate the effect of high-intensity swimming 
      exercise (HISE) on atopic dermatitis (AD). For the study, we established an AD 
      model in BALB/c mice by repeated local exposure of house dust mite extract 
      (Dermatophagoides farinae extract, DFE) and 1-chloro-2,4-dinitrobenzene (CDNB) to 
      the ears. After HISE for 4 weeks, epidermal thickness, mast cell infiltration, 
      serum immunoglobulin E (IgE), and histamine were measured. In addition, the gene 
      expression of interleukin (IL)-5 and IL-31 in the ears was assayed. HISE 
      increased DFE/CDNB-induced AD symptoms based on ear thickness, histopathological 
      analysis, and serum IgE level. Moreover, HISE exercise stimulated mast cell 
      infiltration into the ear, elevation of serum histamine, and DFE/CDNB-induced 
      expression of IL-5 and IL-31 in the ears in the AD model. Taken together, our 
      results indicate the possibility that HISE-induced stress gives rise to AD 
      symptoms through the stimulation of IgE level by increasing IL-5 and IL-31 
      production.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Laboratory of Immunotoxicology, Department of Pharmacology, School of Medicine, 
      Kyungpook National University, Daegu, 700-422, Republic of Korea.
FAU - Kim, Eun-Kyung
AU  - Kim EK
FAU - Choi, Eun-Ju
AU  - Choi EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Interleukin-5)
RN  - 0 (Interleukins)
RN  - 0 (interleukin-31, mouse)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Dermatitis, Atopic/*drug therapy/immunology
MH  - Dinitrochlorobenzene/*chemistry
MH  - Disease Models, Animal
MH  - Epidermis/immunology
MH  - Female
MH  - Histamine/blood
MH  - Immunoglobulin E/blood
MH  - Interleukin-5/metabolism
MH  - Interleukins/metabolism
MH  - Mast Cells/cytology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mites/*chemistry
MH  - Physical Conditioning, Animal
MH  - *Swimming
EDAT- 2014/02/15 06:00
MHDA- 2015/03/04 06:00
CRDT- 2014/02/15 06:00
PHST- 2014/02/15 06:00 [entrez]
PHST- 2014/02/15 06:00 [pubmed]
PHST- 2015/03/04 06:00 [medline]
AID - 10.1007/s10753-014-9843-z [doi]
PST - ppublish
SO  - Inflammation. 2014 Aug;37(4):1179-85. doi: 10.1007/s10753-014-9843-z.