PMID- 2452639
OWN - NLM
STAT- MEDLINE
DCOM- 19880602
LR  - 20131121
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 38
IP  - 1
DP  - 1988 Jan
TI  - Immunopharmacological actions of the new antiallergic drug butyl 
      3'-(1H-tetrazol-5-yl)oxanilate. 2nd communication: inhibitory effects on 
      histamine release from rat mast cells and lung fragments.
PG  - 75-9
AB  - The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic 
      drug, on its ability to inhibit histamine release from both peritoneal mast cells 
      and lung fragments of rats were investigated. WP-833 inhibited in a 
      dose-dependent fashion immunoglobulin E (IgE)-mediated histamine release from 
      mast cells. Such potent inhibition was observed in glucose-free as well as 
      complete Tyrode's solution but neither in Ca2+-free nor D2O-supplemented Tyrode's 
      solution. In addition, WP-833 significantly increased intracellular cyclic 
      adenosine monophosphate (AMP) levels in purified mast cells. On the other hand, 
      WP-833 inhibited compound 48/80-but not calcium ionophore A23187-induced 
      histamine release from normal mast cells. Also both IgE- and IgG-mediated 
      histamine release from lung fragments were inhibited by WP-833. WP-833 showed 
      non-competitive inhibition of cyclic AMP-dependent phosphodiesterase derived from 
      lung preparations.
FAU - Yanagihara, Y
AU  - Yanagihara Y
AD  - Clinical Research Center of Allergy, National Sagamihara Hospital, Kanagawa, 
      Japan.
FAU - Abe, T
AU  - Abe T
FAU - Kuroda, T
AU  - Kuroda T
FAU - Shida, T
AU  - Shida T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Azoles)
RN  - 0 (Dinitrophenols)
RN  - 0 (Tetrazoles)
RN  - 0 (butyl 3-(1H-tetrazol-5-yl)oxanilate)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 3.1.4.17 (3',5'-Cyclic-AMP Phosphodiesterases)
SB  - IM
MH  - 3',5'-Cyclic-AMP Phosphodiesterases/metabolism
MH  - Animals
MH  - Azoles/*pharmacology
MH  - Calcimycin/pharmacology
MH  - Cyclic AMP/metabolism
MH  - Dinitrophenols/immunology
MH  - Histamine Release/*drug effects
MH  - Immunoglobulin E/immunology
MH  - Lung/drug effects/immunology/*metabolism
MH  - Male
MH  - Mast Cells/drug effects/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tetrazoles/*pharmacology
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1988 Jan;38(1):75-9.