PMID- 2452640
OWN - NLM
STAT- MEDLINE
DCOM- 19880602
LR  - 20031114
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 38
IP  - 1
DP  - 1988 Jan
TI  - Immunopharmacological actions of the new antiallergic drug butyl 
      3'-(1H-tetrazol-5-yl)oxanilate. 3rd communication: inhibitory effects on 
      histamine release from lung fragments, Schultz-Dale reaction in isolated tracheal 
      muscle and experimental asthma in guinea pigs.
PG  - 80-3
AB  - The inhibitory effects of butyl 3'-(1H-tetrazol-5-yl) oxanilate (WP-833), a new 
      antiallergic drug, on histamine release from lung fragments, Schultz-Dale (SD) 
      reaction in isolated tracheal muscle and experimental asthma were investigated in 
      guinea pigs passively sensitized with homologous immunoglobulin E (IgE) serum. 
      WP-833 dose-dependently inhibited antigen-induced histamine release from lung 
      fragments. In addition, synergism as to inhibition of histamine release was 
      observed with a combination of WP-833 and isoprenaline but not with that of 
      WP-833 and theophylline. WP-833 also inhibited antigen-mediated SD reaction of 
      isolated tracheal muscle without showing antagonistic actions upon histamine- and 
      leukotriene D4-induced contraction of normal tracheal muscle. Experimental asthma 
      was clearly inhibited in a dose-dependent fashion by oral administration of 
      WP-833.
FAU - Yanagihara, Y
AU  - Yanagihara Y
AD  - Clinical Research Center for Allergy, National Sagamihara Hospital, Kanagawa, 
      Japan.
FAU - Abe, T
AU  - Abe T
FAU - Kuroda, T
AU  - Kuroda T
FAU - Shida, T
AU  - Shida T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Azoles)
RN  - 0 (Dinitrophenols)
RN  - 0 (SRS-A)
RN  - 0 (Tetrazoles)
RN  - 0 (butyl 3-(1H-tetrazol-5-yl)oxanilate)
SB  - IM
MH  - Animals
MH  - Asthma/immunology/*metabolism
MH  - Azoles/*pharmacology
MH  - Dinitrophenols/immunology
MH  - Guinea Pigs
MH  - Histamine Release/*drug effects
MH  - Lung/drug effects/*metabolism
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth/drug effects
MH  - SRS-A/pharmacology
MH  - Tetrazoles/*pharmacology
MH  - Trachea/drug effects/*metabolism
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1988 Jan;38(1):80-3.