PMID- 24528479
OWN - NLM
STAT- MEDLINE
DCOM- 20150127
LR  - 20181202
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 115
IP  - 1
DP  - 2014 Jul
TI  - PCB concentrations and dioxin-like activity in blood samples from Danish school 
      children and their mothers living in urban and rural areas.
PG  - 134-44
LID - 10.1111/bcpt.12214 [doi]
AB  - Human exposure to persistent organic pollutants (POPs) is of major concern due to 
      a diversity of adverse effects from prolonged exposure and bioaccumulation. 
      Manufacturing of polychlorinated biphenyls (PCBs), a subgroup of POPs, has been 
      prohibited for many decades; however, human exposure still occurs due to the 
      persistent nature of the chemicals. The concentrations of the dioxin-like PCB 
      congeners 105, 118 and 156 and the non-dioxin-like PCB congeners 28, 52, 101, 
      138, 153 and 180, p,p'-DDE, p,p'-DDT, o,p'-DDE, o,p'-DDT, HCB and beta-HCH as well 
      as the dioxin-like activity using the AhR transactivity assay were analysed in 
      blood samples from Danish schoolchildren and their mothers in the European 
      framework of the DEMOCOPHES/COPHES projects. The participants were selected from 
      an urban and a rural area, respectively. The PCB concentrations and the AhR-TEQ 
      (TCDD toxic equivalent) were significantly higher in schoolchildren living in the 
      urban area compared with the rural, and for AhR-TEQ, a strong correlation between 
      the mothers and children was observed. We found a significant negative 
      correlation between BMI and PCB concentrations in the children. Finally, in the 
      mothers, there was a positive association between age and PCB concentration. 
      These results show that both PCBs and dioxin-like activity can be measured as 
      biomarkers of exposure and effects in blood samples from children and women. The 
      results indicate that people living in urban areas may be exposed to higher 
      concentrations of PCBs, dioxins and dioxin-like chemicals, which may lead to a 
      greater risk of adverse effects for urban populations.
CI  - (c) 2014 Nordic Association for the Publication of BCPT (former Nordic 
      Pharmacological Society).
FAU - Morck, Thit A
AU  - Morck TA
AD  - Section of Environmental Health, Department of Public Health, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Erdmann, Simon E
AU  - Erdmann SE
FAU - Long, Manhai
AU  - Long M
FAU - Mathiesen, Line
AU  - Mathiesen L
FAU - Nielsen, Flemming
AU  - Nielsen F
FAU - Siersma, Volkert D
AU  - Siersma VD
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
FAU - Knudsen, Lisbeth E
AU  - Knudsen LE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140314
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0S596V3MLH (2,3,3',4,4'-pentachlorobiphenyl)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - 78E4J5IB5J (Mitotane)
RN  - 844ODP31Q0 (2,4,4'-trichlorobiphenyl)
RN  - CIW5S16655 (DDT)
RN  - D4K93Z1TBH (o,p'-DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - DM084YLQ1L (2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Adult
MH  - Body Height
MH  - Body Mass Index
MH  - Body Weight
MH  - Child
MH  - DDT/blood
MH  - Dioxins/*blood/toxicity
MH  - Environmental Pollutants/*blood/toxicity
MH  - Female
MH  - Hexachlorocyclohexane/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitotane/analogs & derivatives/blood
MH  - Mothers
MH  - Polychlorinated Biphenyls/*blood/toxicity
MH  - Rural Population
MH  - Urban Population
EDAT- 2014/02/18 06:00
MHDA- 2015/01/28 06:00
CRDT- 2014/02/18 06:00
PHST- 2013/10/22 00:00 [received]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2015/01/28 06:00 [medline]
AID - 10.1111/bcpt.12214 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2014 Jul;115(1):134-44. doi: 10.1111/bcpt.12214. 
      Epub 2014 Mar 14.