PMID- 24528678
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20221207
IS  - 1751-2980 (Electronic)
IS  - 1751-2972 (Linking)
VI  - 15
IP  - 5
DP  - 2014 May
TI  - Accuracy of diagnosing gastroesophageal reflux disease by GerdQ, esophageal 
      impedance monitoring and histology.
PG  - 230-8
LID - 10.1111/1751-2980.12135 [doi]
AB  - OBJECTIVE: To assess the performance of self-assessment gastroesophageal reflux 
      disease questionnaire (GerdQ), 24-h impedance monitoring, proton pump inhibitor 
      (PPI) test and intercellular space of esophageal mucosal epithelial cells in the 
      diagnosis of gastroesophageal reflux disease (GERD). METHODS: Patients with 
      symptoms suspected of GERD were administered the GerdQ and underwent endoscopy 
      (measurement of intercellular space in the biopsy specimen sampling at 2 cm above 
      the Z-line) and 24-h impedance pH monitoring, together with a 2-week experimental 
      treatment with esomeprazole. RESULTS: A total of 636 patients were included for 
      the final analysis, including 352 with GERD. The sensitivity and specificity of 
      GerdQ and 24-h impedance monitoring for diagnosing GERD were 57.7% and 48.9%, and 
      66.4% and 43.3%, respectively. The sensitivity of 24-h impedance pH monitoring 
      increased to 93.7%. The sensitivity and specificity of dilated intercellular 
      spaces (DIS) (>/=0.9 mum) for diagnosing GERD were 61.2% and 56.1%, respectively, 
      whereas those for PPI test were 70.5% and 44.4%. CONCLUSIONS: GerdQ score or PPI 
      test alone cannot accurately diagnose GERD in a Chinese population suspected of 
      GERD. A definitive diagnosis of GERD still depends on endoscopy or 24-h pH 
      monitoring. 24-h impedance pH monitoring may increase the sensitivity for 
      diagnosing GERD by 20%; however, when used alone, it results in poor specificity 
      in patients without acid suppressive therapy.
CI  - (c) 2014 Chinese Medical Association Shanghai Branch, Chinese Society of 
      Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University 
      School of Medicine and Wiley Publishing Asia Pty Ltd.
FAU - Zhou, Li Ya
AU  - Zhou LY
AD  - Department of Gastroenterology, Peking University Third Hospital, Beijing, China.
FAU - Wang, Ye
AU  - Wang Y
FAU - Lu, Jing Jing
AU  - Lu JJ
FAU - Lin, Lin
AU  - Lin L
FAU - Cui, Rong Li
AU  - Cui RL
FAU - Zhang, He Jun
AU  - Zhang HJ
FAU - Xue, Yan
AU  - Xue Y
FAU - Ding, Shi Gang
AU  - Ding SG
FAU - Lin, San Ren
AU  - Lin SR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Validation Study
PL  - Australia
TA  - J Dig Dis
JT  - Journal of digestive diseases
JID - 101302699
RN  - 0 (Anti-Ulcer Agents)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Adult
MH  - Anti-Ulcer Agents/therapeutic use
MH  - Asian People
MH  - Biopsy
MH  - Electric Impedance
MH  - Endoscopes, Gastrointestinal/*standards
MH  - Esomeprazole/*therapeutic use
MH  - Esophageal pH Monitoring/*standards
MH  - Esophagus/pathology
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mucous Membrane/pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Surveys and Questionnaires/*standards
OTO - NOTNLM
OT  - gastroesophageal reflux disease
OT  - gastroesophageal reflux disease questionnaire
OT  - impedance
OT  - intercellular space
EDAT- 2014/02/18 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/18 06:00
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/1751-2980.12135 [doi]
PST - ppublish
SO  - J Dig Dis. 2014 May;15(5):230-8. doi: 10.1111/1751-2980.12135.