PMID- 24528999
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20151119
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 129
DP  - 2014 Feb
TI  - Circulating levels of p,p'-DDE are related to prevalent hypertension in the 
      elderly.
PG  - 27-31
LID - S0013-9351(13)00204-1 [pii]
LID - 10.1016/j.envres.2013.12.003 [doi]
AB  - BACKGROUND: Polychlorinated biphenyls (PCBs) and dioxin given to experimental 
      animals increase the blood pressure. We therefore investigated if circulating 
      levels of persistent organic pollutants (POPs) were related to hypertension in a 
      population-based sample of men and women. METHODS: One thousand and sixteen 
      subjects aged 70 years were investigated in the Prospective Investigation of the 
      Vasculature in Uppsala Seniors (PIVUS) study. Twenty-three POPs were analyzed 
      using high-resolution gas chromatography/high-resolution mass spectrometry 
      (HRGC/HRMS). Hypertension was defined as a systolic blood pressure >/=140mmHg or a 
      diastolic blood pressure >/=90mmHg, and/or use of antihypertensive medication. 
      RESULTS: Seven hundred and thirty-two subjects (72%) showed hypertension. When 
      the POPs were treated as continuous variables and adjusted for gender only, two 
      PCBs with a low number of chlorine atoms (PCB 105 and 118) were related to 
      prevalent hypertension. Also the OC pesticide p,p'-DDE was related to 
      hypertension. The strongest of these associations was seen for p,p'-DDE (OR 1.35 
      for a 1 SD change, 95% CI 1.17-1.56, p<0.0001). Following further adjustment also 
      for BMI, smoking status, education level and exercise habits, only p,p'-DDE was 
      still significantly related to hypertension (OR 1.23 for a 1 SD change, 95% CI 
      1.06-1.43, p=0.006). CONCLUSION: In this cross-sectional analysis of an elderly 
      population, high levels of circulating levels of p,p'-DDE were associated with 
      prevalent hypertension, further strengthening the experimental findings that POPs 
      might influence blood pressure.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Ullerakersvagen 40, 751 85 Uppsala, Sweden. Electronic address: 
      monica.lind@medsci.uu.se.
FAU - Penell, Johanna
AU  - Penell J
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Ullerakersvagen 40, 751 85 Uppsala, Sweden.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Center, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - van Bavel, Bert
AU  - van Bavel B
AD  - MTM Research Center, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, 
      Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140111
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Data Interpretation, Statistical
MH  - Dichlorodiphenyl Dichloroethylene/*blood/*toxicity
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood/*toxicity
MH  - Female
MH  - Humans
MH  - Hypertension/*blood/chemically induced/epidemiology
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Sweden/epidemiology
OTO - NOTNLM
OT  - DDE
OT  - Elderly
OT  - Hypertension
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
EDAT- 2014/02/18 06:00
MHDA- 2014/04/09 06:00
CRDT- 2014/02/18 06:00
PHST- 2013/07/23 00:00 [received]
PHST- 2013/11/04 00:00 [revised]
PHST- 2013/12/04 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
AID - S0013-9351(13)00204-1 [pii]
AID - 10.1016/j.envres.2013.12.003 [doi]
PST - ppublish
SO  - Environ Res. 2014 Feb;129:27-31. doi: 10.1016/j.envres.2013.12.003. Epub 2014 Jan 
      11.