PMID- 24529042
OWN - NLM
STAT- MEDLINE
DCOM- 20141016
LR  - 20181202
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 76
IP  - 3
DP  - 2014 Mar
TI  - The roles of BDNF, S100B, and oxidative stress in interferon-induced depression 
      and the effect of antidepressant treatment in patients with chronic viral 
      hepatitis: a prospective study.
PG  - 227-32
LID - S0022-3999(14)00005-1 [pii]
LID - 10.1016/j.jpsychores.2014.01.003 [doi]
AB  - OBJECTIVE: The aim of the study was to research the relationship between 
      interferon (IFN) induced depression and sociodemographic characteristics, 
      neurotrophic factors and oxidative stress. METHODS: Sixty four cases, 34 with 
      Chronic Hepatitis B (CHB) and 30 with Chronic Hepatitis C (CHC), were included in 
      the study. The patients were assessed with Structured Clinical Interview for 
      DSM-IV (SCID-I), Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression 
      Rating Scale (HDRS) at baseline on the 2nd and 6th weeks of treatment. S100 
      calcium binding protein B (S100B), brain-derived neurotrophic factor (BDNF), 
      total antioxidant status (TAS) and total oxidative stress (TOS) levels were 
      measured at the same visits. RESULTS: In total, 20 patients were diagnosed with 
      major depression (MD) on the sixth week. A significant relationship was found 
      between depression developed after IFN therapy and baseline HARS scores and the 
      type of IFN-alpha. When the pretreatment levels of HDRS, HARS, S100B, BDNF, TAS, and 
      TOS were compared to those after treatment on the 2nd week, there was a 
      significant increase in HDRS and HARS levels and a significant decrease in the 
      levels of S100B and BDNF. No significant change was determined for TAS and TOS 
      levels. CONCLUSIONS: Our study suggests that the pathogenesis of IFN induced 
      depression may involve neurotrophic factors.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Cicek, Ismet Esra
AU  - Cicek IE
AD  - Department of Psychiatry, Research and Training Hospital, Konya, Turkey. 
      Electronic address: iezeytinci@gmail.com.
FAU - Cicek, Erdinc
AU  - Cicek E
AD  - Department of Psychiatry, University of Mevlana, Faculty of Medicine, Konya, 
      Turkey.
FAU - Kayhan, Fatih
AU  - Kayhan F
AD  - Department of Psychiatry, University of Mevlana, Faculty of Medicine, Konya, 
      Turkey.
FAU - Uguz, Faruk
AU  - Uguz F
AD  - Department of Psychiatry, University of Necmettin Erbakan, Meram Faculty of 
      Medicine, Konya, Turkey.
FAU - Erayman, Ibrahim
AU  - Erayman I
AD  - Department of Clinical Bacteriology and Infectious Disease, University of 
      Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey.
FAU - Kurban, Sevil
AU  - Kurban S
AD  - Department of Biochemistry, University of Necmettin Erbakan, Meram Faculty of 
      Medicine, Konya, Turkey.
FAU - Yerlikaya, F Humeyra
AU  - Yerlikaya FH
AD  - Department of Biochemistry, University of Necmettin Erbakan, Meram Faculty of 
      Medicine, Konya, Turkey.
FAU - Kaya, Nazmiye
AU  - Kaya N
AD  - Department of Biochemistry, University of Necmettin Erbakan, Meram Faculty of 
      Medicine, Konya, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140114
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100B protein, human)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/adverse effects/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/blood/*physiology
MH  - Depression/blood/chemically induced/*drug therapy
MH  - Depressive Disorder, Major/blood/chemically induced/drug therapy
MH  - Female
MH  - Hepatitis B, Chronic/*drug therapy/psychology
MH  - Hepatitis C, Chronic/*drug therapy/psychology
MH  - Humans
MH  - Interferons/*adverse effects/drug effects
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Prospective Studies
MH  - S100 Calcium Binding Protein beta Subunit/blood/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Depression
OT  - Interferon
OT  - Neurotrophic factors
OT  - Oxidative stress
EDAT- 2014/02/18 06:00
MHDA- 2014/10/17 06:00
CRDT- 2014/02/18 06:00
PHST- 2013/08/02 00:00 [received]
PHST- 2013/12/09 00:00 [revised]
PHST- 2014/01/07 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2014/10/17 06:00 [medline]
AID - S0022-3999(14)00005-1 [pii]
AID - 10.1016/j.jpsychores.2014.01.003 [doi]
PST - ppublish
SO  - J Psychosom Res. 2014 Mar;76(3):227-32. doi: 10.1016/j.jpsychores.2014.01.003. 
      Epub 2014 Jan 14.