PMID- 24529365
OWN - NLM
STAT- MEDLINE
DCOM- 20150422
LR  - 20160526
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 153
IP  - 1-3
DP  - 2014 Mar
TI  - Neurocognitive function as a possible marker for remission from clinical high 
      risk for psychosis.
PG  - 48-53
LID - S0920-9964(14)00041-3 [pii]
LID - 10.1016/j.schres.2014.01.018 [doi]
AB  - BACKGROUND: Recent studies revealed that nonconverters at clinical high risk 
      (CHR) for psychosis comprise those who later remit from initial CHR state and 
      those who do not remit and continue to have attenuated positive symptoms. CHR 
      subjects who remit symptomatically are comparable to healthy controls for both 
      baseline and longitudinal symptoms. However, the neurocognitive characteristics 
      of this population are still obscure. METHODS: Seventy-five CHR subjects and 61 
      healthy controls were recruited, and their neurocognitive functions were 
      assessed. CHR subjects were divided into converter, remitter, and non-remitter 
      groups according to their clinical state during a 12 to 24month follow-up. 
      RESULTS: Only the remitter group was comparable to healthy controls in terms of 
      baseline neurocognitive functions. We observed that remitters showed better 
      performance at baseline on tasks of attention, immediate/delayed verbal memory, 
      verbal fluency, and immediate visual memory compared with converters. Moreover, 
      we found that performance on semantic fluency was significantly improved in 
      remitters but declined in non-remitters over the 2-year follow-up; however, there 
      was no significant difference between these two groups at baseline. CONCLUSION: 
      CHR nonconverters who later remit from an initial prodromal state do not show 
      reduced neurocognitive functioning compared with healthy controls at baseline. 
      Therefore, an advanced research diagnostic criterion for a CHR state that 
      considers neurocognitive functions is needed to more precisely predict which 
      patients will develop psychosis.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of 
      Korea; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
FAU - Shin, Ye Seul
AU  - Shin YS
AD  - Department of Brain & Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Shin, Na Young
AU  - Shin NY
AD  - Interdisciplinary Cognitive Science Program, Seoul National University, Seoul, 
      Republic of Korea.
FAU - Kim, Sung Nyun
AU  - Kim SN
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Jang, Joon Hwan
AU  - Jang JH
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kang, Do-Hyung
AU  - Kang DH
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of 
      Korea; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea; 
      Department of Brain & Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea; Interdisciplinary Cognitive Science 
      Program, Seoul National University, Seoul, Republic of Korea; Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea. Electronic address: kwonjs@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140213
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Cognition Disorders/*etiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Neuropsychological Tests
MH  - Predictive Value of Tests
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/*diagnosis
MH  - Recurrence
MH  - Regression Analysis
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Clinical high risk for psychosis
OT  - False positives
OT  - Neurocognition
OT  - Prediction
OT  - Remission
OT  - Semantic fluency
EDAT- 2014/02/18 06:00
MHDA- 2015/04/23 06:00
CRDT- 2014/02/18 06:00
PHST- 2013/10/28 00:00 [received]
PHST- 2013/12/16 00:00 [revised]
PHST- 2014/01/18 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2015/04/23 06:00 [medline]
AID - S0920-9964(14)00041-3 [pii]
AID - 10.1016/j.schres.2014.01.018 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Mar;153(1-3):48-53. doi: 10.1016/j.schres.2014.01.018. Epub 
      2014 Feb 13.