PMID- 24530186
OWN - NLM
STAT- MEDLINE
DCOM- 20141219
LR  - 20220310
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 491-492
DP  - 2014 Sep 1
TI  - Modulation of persistent organic pollutant toxicity through nutritional 
      intervention: emerging opportunities in biomedicine and environmental 
      remediation.
PG  - 11-6
LID - S0048-9697(14)00138-7 [pii]
LID - 10.1016/j.scitotenv.2014.01.109 [doi]
AB  - Environmental pollution is increasing worldwide, and there is evidence that 
      exposure to halogenated persistent organic pollutants (POPs) such as 
      polychlorinated biphenyls can contribute to the pathology of inflammatory 
      diseases such as atherosclerosis, diabetes, and cancer. Pollutant removal from 
      contaminated sites and subsequent pollutant degradation are critical for reducing 
      the long-term health risks associated with exposure. However, complete 
      remediation of a toxicant from the environment is very difficult and 
      cost-prohibitive. Furthermore, remediation technologies often result in the 
      generation of secondary toxicants. Considering these circumstances, 
      environmentally-friendly and sustainable remediation technologies and biomedical 
      solutions to reduce vulnerability to environmental chemical insults need to be 
      explored to reduce the overall health risks associated with exposure to 
      environmental pollutants. We propose that positive lifestyle changes such as 
      healthful nutrition and consumption of diets rich in fruits and vegetables or 
      bioactive nutrients with antioxidant and/or anti-inflammatory properties will 
      reduce the body's vulnerability to environmental stressors and thus reduce 
      toxicant-mediated disease pathologies. Interestingly, emerging evidence now 
      implicates the incorporation of bioactive nutrients, such as plant-derived 
      polyphenols, in technologies focused on the capture, sensing and remediation of 
      halogenated POPs. We propose that human nutritional intervention in concert with 
      the use of natural polyphenol sensing and remediation platforms may provide a 
      sensible means to develop primary and long-term prevention strategies of diseases 
      associated with many environmental toxic insults including halogenated POPs.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Petriello, Michael C
AU  - Petriello MC
AD  - Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; 
      Graduate Center for Toxicology, College of Medicine, University of Kentucky, 
      Lexington, KY 40536, USA.
FAU - Newsome, Bradley J
AU  - Newsome BJ
AD  - Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; 
      Department of Chemistry, College of Arts and Sciences, University of Kentucky, 
      Lexington, KY 40506, USA.
FAU - Dziubla, Thomas D
AU  - Dziubla TD
AD  - Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; 
      Department of Chemical and Materials Engineering, College of Engineering, 
      University of Kentucky, Lexington, KY 40506, USA.
FAU - Hilt, J Zach
AU  - Hilt JZ
AD  - Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; 
      Department of Chemical and Materials Engineering, College of Engineering, 
      University of Kentucky, Lexington, KY 40506, USA.
FAU - Bhattacharyya, Dibakar
AU  - Bhattacharyya D
AD  - Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; 
      Department of Chemical and Materials Engineering, College of Engineering, 
      University of Kentucky, Lexington, KY 40506, USA.
FAU - Hennig, Bernhard
AU  - Hennig B
AD  - Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; 
      Graduate Center for Toxicology, College of Medicine, University of Kentucky, 
      Lexington, KY 40536, USA; Department of Animal and Food Sciences, College of 
      Agriculture Food and Environment, University of Kentucky, Lexington, KY 40546, 
      USA.
LA  - eng
GR  - P42 ES007380/ES/NIEHS NIH HHS/United States
GR  - P42ES007380/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140213
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Antioxidants)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - *Antioxidants
MH  - Environmental Pollutants/*toxicity
MH  - Environmental Pollution/*statistics & numerical data
MH  - Environmental Restoration and Remediation/*methods
MH  - Food
MH  - Humans
MH  - Nutritive Value
PMC - PMC4077968
MID - NIHMS567838
OTO - NOTNLM
OT  - Antioxidant response
OT  - Nutrition
OT  - Oxidative stress
OT  - POP toxicity
OT  - Polyphenol
OT  - Sustainable remediation
EDAT- 2014/02/18 06:00
MHDA- 2014/12/20 06:00
PMCR- 2015/09/01
CRDT- 2014/02/18 06:00
PHST- 2013/11/04 00:00 [received]
PHST- 2014/01/27 00:00 [revised]
PHST- 2014/01/28 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2014/12/20 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - S0048-9697(14)00138-7 [pii]
AID - 10.1016/j.scitotenv.2014.01.109 [doi]
PST - ppublish
SO  - Sci Total Environ. 2014 Sep 1;491-492:11-6. doi: 10.1016/j.scitotenv.2014.01.109. 
      Epub 2014 Feb 13.