PMID- 24530657
OWN - NLM
STAT- MEDLINE
DCOM- 20150213
LR  - 20220317
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 266
DP  - 2014 Apr 25
TI  - Taurine improves functional and histological outcomes and reduces inflammation in 
      traumatic brain injury.
PG  - 56-65
LID - S0306-4522(14)00102-X [pii]
LID - 10.1016/j.neuroscience.2014.02.006 [doi]
AB  - We investigated the effect of taurine on inflammatory cytokine expression, on 
      astrocyte activity and cerebral edema and functional outcomes, following 
      traumatic brain injury (TBI) in rats. 72 rats were randomly divided into sham, 
      TBI and Taurine groups. Rats subjected to moderate lateral fluid percussion 
      injury were injected intravenously with taurine (200mg/kg) or saline immediately 
      after injury or daily for 7days. Functional outcome was evaluated using Modified 
      Neurological Severity Score (mNSS). Glial fibrillary acidic protein (GFAP) of the 
      brain was measured using immunofluorescence. Concentration of 23 cytokines and 
      chemokines in the injured cortex at 1 and 7days after TBI was assessed by Luminex 
      xMAP technology. The results showed that taurine significantly improved 
      functional recovery except 1day, reduced accumulation of GFAP and water content 
      in the penumbral region at 7days after TBI. Compared with the TBI group, taurine 
      significantly suppressed growth-related oncogene (GRO/KC) and interleukin (IL)-1beta 
      levels while elevating the levels of regulated on activation, normal T cell 
      expressed and secreted (RANTES) at 1day. And taurine markedly decreased the level 
      of 17 cytokine: eotaxin, Granulocyte colony-stimulating factor (G-CSF), 
      Granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-gamma 
      (IFN-gamma), IL-1alpha, IL-1beta, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-13, IL-17, leptin, 
      monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), 
      vascular endothelial growth factor (VEGF), and only increased the level of MIP-1alpha 
      in a week. The results suggest that taurine effectively mitigates the severity of 
      brain damage in TBI by attenuating the increase of astrocyte activity and edema 
      as well as pro-inflammatory cytokines.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Su, Y
AU  - Su Y
AD  - The Graduate School, Tianjin Medical University, Tianjin 300070, PR China.
FAU - Fan, W
AU  - Fan W
AD  - Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin 300060, PR 
      China.
FAU - Ma, Z
AU  - Ma Z
AD  - Baoding NO. 1 Hospital, Baoding, Hebei 071000, PR China.
FAU - Wen, X
AU  - Wen X
AD  - The Graduate School, Tianjin Medical University, Tianjin 300070, PR China.
FAU - Wang, W
AU  - Wang W
AD  - Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin 300060, PR 
      China.
FAU - Wu, Q
AU  - Wu Q
AD  - Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin 300060, PR 
      China.
FAU - Huang, H
AU  - Huang H
AD  - Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin 300060, PR 
      China. Electronic address: huanghuiling@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140214
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Neuroprotective Agents)
RN  - 1EQV5MLY3D (Taurine)
SB  - IM
MH  - Animals
MH  - Brain Injuries/*pathology
MH  - Disease Models, Animal
MH  - Fluorescent Antibody Technique
MH  - Inflammation/prevention & control
MH  - Male
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function/*drug effects
MH  - Taurine/*pharmacology
OTO - NOTNLM
OT  - Luminex
OT  - cytokine
OT  - inflammation
OT  - taurine
OT  - traumatic brain injury
EDAT- 2014/02/18 06:00
MHDA- 2015/02/14 06:00
CRDT- 2014/02/18 06:00
PHST- 2013/11/09 00:00 [received]
PHST- 2014/01/13 00:00 [revised]
PHST- 2014/02/05 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2015/02/14 06:00 [medline]
AID - S0306-4522(14)00102-X [pii]
AID - 10.1016/j.neuroscience.2014.02.006 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Apr 25;266:56-65. doi: 10.1016/j.neuroscience.2014.02.006. 
      Epub 2014 Feb 14.