PMID- 24531049
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20140430
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 92
DP  - 2014 May 15
TI  - Resting-state fMRI reveals functional connectivity between face-selective 
      perirhinal cortex and the fusiform face area related to face inversion.
PG  - 349-55
LID - S1053-8119(14)00096-2 [pii]
LID - 10.1016/j.neuroimage.2014.02.005 [doi]
AB  - Studies examining the neural correlates of face perception and recognition in 
      humans have revealed multiple brain regions that appear to play a specialized 
      role in face processing. These include an anterior portion of perirhinal cortex 
      (PrC) that appears to be homologous to the face-selective 'anterior face patch' 
      recently reported in non-human primates. Electrical stimulation studies in the 
      macaque indicate that the anterior face patch is strongly connected with other 
      face-selective patches of cortex, even in the absence of face stimuli. The 
      intrinsic functional connectivity of face-selective PrC and other regions of the 
      face-processing network in humans are currently less well understood. Here, we 
      examined resting-state fMRI connectivity across five face-selective regions in 
      the right hemisphere that were identified with separate functional localizer 
      scans: the PrC, amygdala (Amg), superior temporal sulcus, fusiform face area 
      (FFA), and occipital face area. A partial correlation technique, controlling for 
      fluctuations in occipitotemporal cortex that were not face specific, revealed 
      connectivity between the PrC and the FFA, as well as the Amg. When examining the 
      'unique' connectivity of PrC within this face processing network, we found that 
      the connectivity between the PrC and the FFA as well as that between the PrC and 
      the Amg persisted even after controlling for potential mediating effects of other 
      face-selective regions. Lastly, we examined the behavioral relevance of PrC 
      connectivity by examining inter-individual differences in resting-state 
      fluctuations in relation to differences in behavioral performance for a 
      forced-choice recognition memory task that involved judgments on upright and 
      inverted faces. This analysis revealed a significant correlation between the 
      increased accuracy for upright faces (i.e., the face inversion effect) and the 
      strength of connectivity between the PrC and the FFA. Together, these findings 
      point to a high degree of functional integration of face-selective aspects of PrC 
      in the face processing network with notable behavioral relevance.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - O'Neil, Edward B
AU  - O'Neil EB
AD  - The Brain and Mind Institute and Department of Psychology, University of Western 
      Ontario, London, Ontario N6A 5C2, Canada. Electronic address: edoneil@gmail.com.
FAU - Hutchison, R Matthew
AU  - Hutchison RM
AD  - Robarts Research Institute, University of Western Ontario, London, Ontario N6A 
      5C2, Canada.
FAU - McLean, D Adam
AU  - McLean DA
AD  - The Brain and Mind Institute and Department of Psychology, University of Western 
      Ontario, London, Ontario N6A 5C2, Canada.
FAU - Kohler, Stefan
AU  - Kohler S
AD  - The Brain and Mind Institute and Department of Psychology, University of Western 
      Ontario, London, Ontario N6A 5C2, Canada; Rotman Research Institute, Baycrest 
      Centre, Toronto, Ontario M6A 2E1, Canada. Electronic address: stefank@uwo.ca.
LA  - eng
GR  - MOP93644/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140212
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/*physiology
MH  - Connectome/*methods
MH  - *Face
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Net/*physiology
MH  - Neural Pathways/physiology
MH  - Pattern Recognition, Visual/*physiology
MH  - Rest/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Anterior face patch
OT  - FFA
OT  - Face inversion
OT  - Perirhinal cortex
OT  - Resting-state connectivity
OT  - fMRI
EDAT- 2014/02/18 06:00
MHDA- 2014/12/19 06:00
CRDT- 2014/02/18 06:00
PHST- 2013/09/26 00:00 [received]
PHST- 2014/01/28 00:00 [revised]
PHST- 2014/02/02 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
AID - S1053-8119(14)00096-2 [pii]
AID - 10.1016/j.neuroimage.2014.02.005 [doi]
PST - ppublish
SO  - Neuroimage. 2014 May 15;92:349-55. doi: 10.1016/j.neuroimage.2014.02.005. Epub 
      2014 Feb 12.