PMID- 24532590
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20140411
IS  - 2049-632X (Electronic)
IS  - 2049-632X (Linking)
VI  - 70
IP  - 3
DP  - 2014 Apr
TI  - Antifouling polyurethanes to fight device-related staphylococcal infections: 
      synthesis, characterization, and antibiofilm efficacy.
PG  - 401-7
LID - 10.1111/2049-632X.12155 [doi]
AB  - In hospital settings, biofilm-based medical device-related infections are 
      considered a threat to patients, the sessile growing bacteria playing a key role 
      in the spreading of healthcare-associated infections. In recent decades, the 
      design of antifouling coatings for medical devices able to prevent microbial 
      adhesiveness has emerged as one of the most promising strategies to face this 
      important issue. In order to obtain suitable antifouling materials, segmented 
      polyurethanes characterized by a hard/soft domain structure, having the same hard 
      domain but a variable soft domain, have been synthesized. The soft domain was 
      constituted by one of the following macrodiols: polypropylenoxide (PPO), 
      polycaprolactide (PCL), and poly-l-lactide (PLA). The effects of the polymer 
      hydrophilicity and the degree of hard/soft domain separation on antifouling 
      properties of the synthesized polyurethanes were investigated. Microbial 
      adherence assays evidenced as the polymers containing PCL or PLA were able to 
      significantly reduce the adhesion of Staphylococcus epidermidis with respect to 
      the PPO-containing polymer.
CI  - (c) 2014 Federation of European Microbiological Societies. Published by John Wiley 
      & Sons Ltd. All rights reserved.
FAU - Francolini, Iolanda
AU  - Francolini I
AD  - Department of Chemistry, Sapienza University, Rome, Italy.
FAU - Donelli, Gianfranco
AU  - Donelli G
FAU - Vuotto, Claudia
AU  - Vuotto C
FAU - Baroncini, Fabrizio Alessandro
AU  - Baroncini FA
FAU - Stoodley, Paul
AU  - Stoodley P
FAU - Taresco, Vincenzo
AU  - Taresco V
FAU - Martinelli, Andrea
AU  - Martinelli A
FAU - D'Ilario, Lucio
AU  - D'Ilario L
FAU - Piozzi, Antonella
AU  - Piozzi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140317
PL  - United States
TA  - Pathog Dis
JT  - Pathogens and disease
JID - 101595366
RN  - 0 (Polyurethanes)
SB  - IM
MH  - Bacterial Adhesion
MH  - Biofilms/*drug effects
MH  - Equipment and Supplies/*microbiology
MH  - Humans
MH  - Polyurethanes/*chemistry/*pharmacology
MH  - Staphylococcus epidermidis/*drug effects/*physiology
MH  - Surface Properties
MH  - Thermodynamics
OTO - NOTNLM
OT  - Staphylococcus epidermidis
OT  - antifouling coatings
OT  - infections
OT  - medical devices
OT  - microbial biofilms
OT  - polyurethanes
EDAT- 2014/02/18 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/18 06:00
PHST- 2013/11/29 00:00 [received]
PHST- 2014/01/29 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/2049-632X.12155 [doi]
PST - ppublish
SO  - Pathog Dis. 2014 Apr;70(3):401-7. doi: 10.1111/2049-632X.12155. Epub 2014 Mar 17.