PMID- 24534280
OWN - NLM
STAT- MEDLINE
DCOM- 20140602
LR  - 20140331
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 101
IP  - 4
DP  - 2014 Apr
TI  - Synchronous regulation of the determinants of endometrial receptivity to 
      interleukin 1 at key stages of early embryo implantation in vivo.
PG  - 1183-93
LID - S0015-0282(14)00041-7 [pii]
LID - 10.1016/j.fertnstert.2014.01.011 [doi]
AB  - OBJECTIVE: To investigate the expression kinetics of interleukin-1 receptors 
      (IL-1R), receptor antagonist (IL-1RN), and monocyte chemotactic protein 1 (MCP-1) 
      throughout early gestation in mice. DESIGN: Assessment of IL-1R, IL-1RN, and 
      MCP-1 throughout early pregnancy. SETTING: Reproduction laboratory. ANIMAL(S): 
      B6C3F1 female mice bred with fertile males of the same strain. INTERVENTION(S): 
      Collection of endometrial tissue at necropsy from nonimplanted and implanted 
      sites. MAIN OUTCOME MEASURE(S): IL-1R, IL-1RN, and MCP-1 mRNA expression by 
      quantitative reverse-transcription polymerase chain reaction and protein 
      expression by enzyme-linked immunosorbent assay and immunohistochemistry. 
      RESULT(S): The expression of the signaling IL-1R1 significantly increased in the 
      first 2 days of gestation, which corresponded to the inflammatory-like period 
      triggered by the seminal fluid, before increasing again at the implantation 
      window and lasting throughout embryo implantation. The expression of inhibitory 
      IL-1R2 and IL-1RN concomitantly increased during gestational days 1-2 but 
      remained low, particularly within the embryo implantation sites and throughout 
      the implantation period. The expression of MCP-1 significantly increased only at 
      the embryo implantation sites and showed a significant positive correlation with 
      IL-1R1 expression. CONCLUSION(S): Our data identified for the first time 
      synchronous changes in endometrial IL-1R throughout early gestation in vivo and 
      point to a deep modulation of endometrial receptivity to IL-1 by embryo-driven 
      signals. This may play a key role in the creation of a receptive phenotype in the 
      maternal endometrium and represent a key mechanism underlying embryo 
      implantation.
CI  - Copyright (c) 2014 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Bourdiec, Amelie
AU  - Bourdiec A
AD  - Endocrinologie de la Reproduction, Centre Hospitalier Universitaire de Quebec, 
      Hopital Saint-Francois d'Assise, Faculte de Medecine, Universite Laval, Montreal, 
      Quebec, Canada.
FAU - Martel, Valery
AU  - Martel V
AD  - Endocrinologie de la Reproduction, Centre Hospitalier Universitaire de Quebec, 
      Hopital Saint-Francois d'Assise, Faculte de Medecine, Universite Laval, Montreal, 
      Quebec, Canada.
FAU - Akoum, Ali
AU  - Akoum A
AD  - Endocrinologie de la Reproduction, Centre Hospitalier Universitaire de Quebec, 
      Hopital Saint-Francois d'Assise, Faculte de Medecine, Universite Laval, Montreal, 
      Quebec, Canada; Departement d'Obstetrique, Gynecologie et Reproduction, Faculte 
      de Medecine, Universite Laval, Montreal, Quebec, Canada. Electronic address: 
      ali.akoum@crsfa.ulaval.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140215
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Interleukin-1 Type I)
SB  - IM
MH  - Animals
MH  - Embryo Implantation/*physiology
MH  - Endometrium/*physiology
MH  - Female
MH  - Interleukin 1 Receptor Antagonist Protein/*metabolism
MH  - Interleukin-1/*metabolism
MH  - Mice
MH  - Pregnancy
MH  - Receptors, CCR2/*metabolism
MH  - Receptors, Interleukin-1 Type I/*metabolism
OTO - NOTNLM
OT  - Early gestation
OT  - embryo implantation
OT  - endometrium
OT  - interleukin-1
EDAT- 2014/02/19 06:00
MHDA- 2014/06/03 06:00
CRDT- 2014/02/19 06:00
PHST- 2013/09/10 00:00 [received]
PHST- 2014/01/09 00:00 [revised]
PHST- 2014/01/09 00:00 [accepted]
PHST- 2014/02/19 06:00 [entrez]
PHST- 2014/02/19 06:00 [pubmed]
PHST- 2014/06/03 06:00 [medline]
AID - S0015-0282(14)00041-7 [pii]
AID - 10.1016/j.fertnstert.2014.01.011 [doi]
PST - ppublish
SO  - Fertil Steril. 2014 Apr;101(4):1183-93. doi: 10.1016/j.fertnstert.2014.01.011. 
      Epub 2014 Feb 15.