PMID- 24534511
OWN - NLM
STAT- MEDLINE
DCOM- 20151127
LR  - 20161125
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 97
IP  - 4
DP  - 2014
TI  - Effects of lipid and propionic acid infusions on feed intake of lactating dairy 
      cows.
PG  - 2297-304
LID - S0022-0302(14)00111-8 [pii]
LID - 10.3168/jds.2013-7066 [doi]
AB  - Propionic acid is more hypophagic for cows with elevated hepatic acetyl coenzyme 
      A (CoA) concentration in the postpartum period. The objective of this experiment 
      was to evaluate the interaction of hepatic acetyl CoA concentration, which is 
      elevated by intravenous lipid infusion, and intraruminal propionic acid infusion 
      on feed intake and feeding behavior responses of lactating cows. Eight 
      multiparous, ruminally cannulated, Holstein dairy cows past peak lactation were 
      used in a replicated 4x4 Latin square experiment with a 2x2 factorial arrangement 
      of treatments. Treatments were propionic acid (PI) infused intraruminally at 
      0.5mol/h for 18h starting 6h before feeding and behavior monitoring or sham 
      control (CO), and intravenous jugular infusion of lipid (LI, Intralipid 20%; 
      Baxter US, Deerfield, IL) or saline (SI, 0.9% NaCl; Baxter US) infused at 250mL/h 
      for 12h before feeding and behavior monitoring, and then 500mL/h for 12h after 
      feeding. Changes in plasma concentrations of metabolites and hormones and hepatic 
      acetyl CoA from before infusion until the end of infusion were evaluated. We 
      observed a tendency for an interaction between PI and LI for the change in plasma 
      nonesterified fatty acid (NEFA) concentration from the preliminary day to the end 
      of the infusion period. Infusion of propionic acid decreased dry matter intake 
      (DMI) 15% compared with CO, but lipid infusion did not affect DMI over the 12h 
      following feeding. Infusion of propionic acid tended to decrease hepatic acetyl 
      CoA concentration from the preliminary day to the end of the infusion compared 
      with CO, consistent with PI decreasing DMI by stimulating oxidation of acetyl 
      CoA. Contrary to our expectations, LI did not increase concentration of NEFA or 
      beta-hydroxybutyrate in plasma, concentration of acetyl CoA in the liver, or milk 
      fat yield, suggesting that the infused lipid was stored or oxidized by 
      extra-hepatic tissues. As a result, we detected no interaction between PI and LI 
      for DMI. Although the effect of PI on DMI was consistent with our previous 
      results, this lipid infusion model using cows past peak lactation was not useful 
      to simulate the lipolytic state of cows in the postpartum period in this 
      experiment.
CI  - Copyright (c) 2014 American Dairy Science Association. Published by Elsevier Inc. 
      All rights reserved.
FAU - Stocks, S E
AU  - Stocks SE
AD  - Department of Animal Science, Michigan State University, East Lansing 48824-1225.
FAU - Allen, M S
AU  - Allen MS
AD  - Department of Animal Science, Michigan State University, East Lansing 48824-1225. 
      Electronic address: allenm@msu.edu.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140215
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hormones)
RN  - 0 (Propionates)
RN  - 72-89-9 (Acetyl Coenzyme A)
RN  - JHU490RVYR (propionic acid)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid/blood
MH  - Acetyl Coenzyme A/metabolism
MH  - *Animal Feed
MH  - Animals
MH  - Cattle
MH  - Diet/veterinary
MH  - Dietary Fats/*administration & dosage
MH  - Fatty Acids, Nonesterified/blood
MH  - *Feeding Behavior
MH  - Female
MH  - Hormones/blood
MH  - Hydrogen-Ion Concentration
MH  - Lactation
MH  - Lipolysis
MH  - Liver/drug effects/enzymology
MH  - Milk/chemistry
MH  - Postpartum Period
MH  - Propionates/*administration & dosage
MH  - Rumen/drug effects/metabolism
OTO - NOTNLM
OT  - hepatic oxidation
OT  - hypophagia
OT  - lipid metabolism
OT  - propionate metabolism
EDAT- 2014/02/19 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/02/19 06:00
PHST- 2013/05/25 00:00 [received]
PHST- 2013/12/05 00:00 [accepted]
PHST- 2014/02/19 06:00 [entrez]
PHST- 2014/02/19 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0022-0302(14)00111-8 [pii]
AID - 10.3168/jds.2013-7066 [doi]
PST - ppublish
SO  - J Dairy Sci. 2014;97(4):2297-304. doi: 10.3168/jds.2013-7066. Epub 2014 Feb 15.