PMID- 2453456
OWN - NLM
STAT- MEDLINE
DCOM- 19880711
LR  - 20190824
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 17
IP  - 3
DP  - 1988 Mar
TI  - Synergy between interferons and monokines in MHC induction on brain endothelium.
PG  - 267-71
AB  - Rat brain endothelial cells were cultured as confluent monolayers and stimulated 
      with combinations of interferon-beta (IFN beta), interferon-gamma (IFN gamma), 
      tumour necrosis factor (TNF) and interleukin 1 (IL-1). After 4 days of 
      stimulation the cell surface expression of class I and class II MHC molecules was 
      quantitated by enzyme immunoassay. TNF by itself enhances class I expression and 
      it synergises with IFN gamma in enhancing class I expression and inducing class 
      II. IL-1 does not affect class I expression, nor does it synergise with IFN gamma 
      in this respect. High doses of IL-1 slightly reduce IFN gamma mediated class II 
      induction, but have no synergistic effect at lower doses. IFN beta stimulates 
      class I weakly and induced class II in one experiment but the effects seen when 
      IFN gamma and IFN beta were used together were additive, not synergistic. IFN 
      gamma is the most potent modulator of MHC expression on these cells, although TNF 
      acts as a strong co-stimulator, while IL-1 and IFN beta have only minor effects.
FAU - Male, D
AU  - Male D
AD  - Department of Neuropathology, Institute of Psychiatry, London, U.K.
FAU - Pryce, G
AU  - Pryce G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Biological Products)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (Interferon Type I)
RN  - 0 (Interleukin-1)
RN  - 0 (Monokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Biological Products/*pharmacology
MH  - Brain/*immunology
MH  - Cells, Cultured
MH  - Drug Synergism
MH  - Endothelium/immunology
MH  - Histocompatibility Antigens
MH  - Interferon Type I/pharmacology
MH  - Interferon-gamma/pharmacology
MH  - Interferons/*pharmacology
MH  - Interleukin-1/pharmacology
MH  - Monokines
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 1988/03/01 00:00
MHDA- 1988/03/01 00:01
CRDT- 1988/03/01 00:00
PHST- 1988/03/01 00:00 [pubmed]
PHST- 1988/03/01 00:01 [medline]
PHST- 1988/03/01 00:00 [entrez]
AID - 0165-2478(88)90040-5 [pii]
AID - 10.1016/0165-2478(88)90040-5 [doi]
PST - ppublish
SO  - Immunol Lett. 1988 Mar;17(3):267-71. doi: 10.1016/0165-2478(88)90040-5.