PMID- 24548565
OWN - NLM
STAT- MEDLINE
DCOM- 20140615
LR  - 20220410
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 588
IP  - 8
DP  - 2014 Apr 17
TI  - Differentiating connexin hemichannels and pannexin channels in cellular ATP 
      release.
PG  - 1379-88
LID - S0014-5793(14)00123-9 [pii]
LID - 10.1016/j.febslet.2014.02.004 [doi]
AB  - Adenosine triphosphate (ATP) plays a fundamental role in cellular communication, 
      with its extracellular accumulation triggering purinergic signaling cascades in a 
      diversity of cell types. While the roles for purinergic signaling in health and 
      disease have been well established, identification and differentiation of the 
      specific mechanisms controlling cellular ATP release is less well understood. 
      Multiple mechanisms have been proposed to regulate ATP release with connexin (Cx) 
      hemichannels and pannexin (Panx) channels receiving major focus. However, 
      segregating the specific roles of Panxs and Cxs in ATP release in a plethora of 
      physiological and pathological contexts has remained enigmatic. This multifaceted 
      problem has arisen from the selectivity of pharmacological inhibitors for Panxs 
      and Cxs, methodological differences in assessing Panx and Cx function and the 
      potential compensation by other isoforms in gene silencing and genetic knockout 
      models. Consequently, there remains a void in the current understanding of 
      specific contributions of Panxs and Cxs in releasing ATP during homeostasis and 
      disease. Differentiating the distinct signaling pathways that regulate these two 
      channels will advance our current knowledge of cellular communication and aid in 
      the development of novel rationally-designed drugs for modulation of Panx and Cx 
      activity, respectively.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Lohman, Alexander W
AU  - Lohman AW
AD  - Department of Molecular Physiology and Biophysics, University of Virginia, 
      Charlottesville, VA 22098, United States; Robert M. Berne Cardiovascular Research 
      Center, University of Virginia, Charlottesville, VA 22908, United States.
FAU - Isakson, Brant E
AU  - Isakson BE
AD  - Department of Molecular Physiology and Biophysics, University of Virginia, 
      Charlottesville, VA 22098, United States; Robert M. Berne Cardiovascular Research 
      Center, University of Virginia, Charlottesville, VA 22908, United States. 
      Electronic address: brant@virginia.edu.
LA  - eng
GR  - R01 HL088554/HL/NHLBI NIH HHS/United States
GR  - R21 HL107963/HL/NHLBI NIH HHS/United States
GR  - HL107963/HL/NHLBI NIH HHS/United States
GR  - HL088554/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140215
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Connexins)
RN  - 0 (Receptors, Purinergic)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/*metabolism
MH  - Animals
MH  - Connexins/antagonists & inhibitors/classification/genetics/*metabolism
MH  - Humans
MH  - Intercellular Junctions/classification/metabolism
MH  - Receptors, Purinergic/metabolism
PMC - PMC3996918
MID - NIHMS572455
OTO - NOTNLM
OT  - ATP
OT  - Connexin hemichannel
OT  - Pannexin channel
OT  - Purinergic
OT  - Receptor
EDAT- 2014/02/20 06:00
MHDA- 2014/06/16 06:00
PMCR- 2015/04/17
CRDT- 2014/02/20 06:00
PHST- 2014/01/05 00:00 [received]
PHST- 2014/02/06 00:00 [revised]
PHST- 2014/02/06 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/06/16 06:00 [medline]
PHST- 2015/04/17 00:00 [pmc-release]
AID - S0014-5793(14)00123-9 [pii]
AID - 10.1016/j.febslet.2014.02.004 [doi]
PST - ppublish
SO  - FEBS Lett. 2014 Apr 17;588(8):1379-88. doi: 10.1016/j.febslet.2014.02.004. Epub 
      2014 Feb 15.