PMID- 24548578
OWN - NLM
STAT- MEDLINE
DCOM- 20141008
LR  - 20221207
IS  - 1871-403X (Print)
IS  - 1871-403X (Linking)
VI  - 8
IP  - 1
DP  - 2014 Jan-Feb
TI  - Decreased plasma levels of brain-derived neurotrophic factor and its relationship 
      with obesity and birth weight in obese Japanese children.
PG  - e63-9
LID - S1871-403X(12)00039-7 [pii]
LID - 10.1016/j.orcp.2012.07.003 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays important roles in the 
      central regulation of food intake and body weight control. However, little is 
      known about the role of BDNF in childhood obesity. OBJECTIVE: To investigate the 
      relationship between plasma levels of BDNF and anthropometric factors, metabolic 
      derangements due to obesity, adipocytokine levels and birth weight in obese 
      Japanese children. SUBJECTS AND METHODS: Sixty-six obese Japanese children aged 
      from 5 to 15 years old were enrolled. The age-matched control group consisted of 
      32 non-obese healthy children. The plasma levels of BDNF and adipocytokines 
      (leptin and adiponectin) were assayed using ELISA techniques. RESULTS: The mean 
      BMI Z-scores were -0.67, +2.15 and +3.39 for the non-obese control children, 
      obese (BMI >/= 90th percentile, <99th percentile) and morbidly obese (BMI >/= 99th 
      percentile), respectively. The plasma levels of BDNF were significantly decreased 
      in the morbidly obese children compared with the levels in the obese and 
      non-obese control children (507 +/- 33 pg/ml vs. 626 +/- 46 pg/ml, 621 +/- 35 pg/ml, p 
      < 0.05). Univariate linear regression analysis showed that the plasma level of 
      BDNF was positively correlated with birth weight (r = 0.264, p < 0.05) and 
      inversely correlated with the BMI Z-score (r = -0.314, p < 0.05). Multivariate 
      forward stepwise linear regression analysis revealed that the birth weight and 
      BMI Z-score are independent predictors of the plasma BDNF level. CONCLUSION: The 
      plasma level of BDNF, which is decreased in morbidly obese children, is 
      associated with birth weight and the BMI Z-score. Our results suggest that BDNF 
      may play important roles in the development and pathophysiology of childhood 
      obesity.
CI  - A(c) 2014 Asian Oceanian Association for the Study of Obesity . Published by 
      Elsevier Ltd. All rights reserved.
FAU - Araki, Shunsuke
AU  - Araki S
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan. Electronic 
      address:arashun@med.uoeh-u.ac.jp.
FAU - Yamamoto, Yukiyo
AU  - Yamamoto Y
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
FAU - Dobashi, Kazushige
AU  - Dobashi K
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
FAU - Asayama, Kohtaro
AU  - Asayama K
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
FAU - Kusuhara, Koichi
AU  - Kusuhara K
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Obes Res Clin Pract
JT  - Obesity research & clinical practice
JID - 101303911
RN  - 0 (Adiponectin)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Leptin)
SB  - IM
MH  - Adiponectin/blood
MH  - Adolescent
MH  - Asian People
MH  - *Birth Weight
MH  - *Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Leptin/blood
MH  - Male
MH  - Obesity, Morbid/*blood
MH  - Pediatric Obesity/*blood
EDAT- 2014/02/20 06:00
MHDA- 2014/10/09 06:00
CRDT- 2014/02/20 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/07/27 00:00 [revised]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/10/09 06:00 [medline]
AID - S1871-403X(12)00039-7 [pii]
AID - 10.1016/j.orcp.2012.07.003 [doi]
PST - ppublish
SO  - Obes Res Clin Pract. 2014 Jan-Feb;8(1):e63-9. doi: 10.1016/j.orcp.2012.07.003.