PMID- 24548626
OWN - NLM
STAT- MEDLINE
DCOM- 20141126
LR  - 20140328
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 564
DP  - 2014 Apr 3
TI  - Immunohistochemical localization of brain-derived neurotrophic factor and glial 
      cell line-derived neurotrophic factor in the superior olivary complex of mice 
      after radiofrequency exposure.
PG  - 78-82
LID - S0304-3940(14)00108-6 [pii]
LID - 10.1016/j.neulet.2014.02.013 [doi]
AB  - Raising health concerns about the biological effects from radiofrequency 
      exposure, even with conflicting results, has prompted calls for formulation of a 
      guideline of the biological safety level. Given the close proximity between a 
      mobile phone and the ear, it has been suggested that the central auditory system 
      may be detrimentally influenced by radiofrequency exposure. In the auditory 
      system, neurotrophins are important in the regulation of neuron survival, 
      especially mammalian cochlear neurons. Neurotrophic factors like brain-derived 
      neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) present 
      in the auditory system are responsible for the maintenance of auditory neurons. 
      BDNF and GDNF may protect against acoustic trauma and prevent from hearing 
      defect. The present study applied radiofrequency at a specific absorption rate 
      (SAR) of 1.6W/kg (E1.6) or 0W/kg group to determine the distribution of BDNF and 
      GDNF in the nuclei of superior olivary complex (SOC). In the E1.6 group, 
      significant decrements of BDNF immunoreactivity (IR) were noted in the lateral 
      superior olive, medial superior olive, superior paraolivary nucleus and medial 
      nucleus of the trapezoid body. GDNF IR was also significantly decreased (p<0.001) 
      in all SOC nuclei of the E1.6 group. The decrease in the IR of these neurotrophic 
      factors in the SOC of the E1.6 group suggests a detrimental effect of RF exposure 
      in the auditory nuclei.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Maskey, Dhiraj
AU  - Maskey D
AD  - Department of Anatomy, Nepalese Army Institute of Health Sciences - College of 
      Medicine, GPO Box No: 10160 Bhandarkhal, Sanobharyang, Kathmandu, Nepal; 
      Department of Anatomy, Institute of Medical Center, Dankook University, San#29, 
      Anseo-dong, Cheonan-si, Chungnam 330-714. South Korea.
FAU - Kim, Myeung Ju
AU  - Kim MJ
AD  - Department of Anatomy, Institute of Medical Center, Dankook University, San#29, 
      Anseo-dong, Cheonan-si, Chungnam 330-714. South Korea. Electronic address: 
      mjukim99@dankook.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20140216
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*analysis
MH  - Glial Cell Line-Derived Neurotrophic Factor/*analysis
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Olivary Nucleus/*chemistry
MH  - Radio Waves/*adverse effects
OTO - NOTNLM
OT  - BDNF
OT  - GDNF
OT  - Nuclei
OT  - Radiofrequency
OT  - Superior olivary complex (SOC)
EDAT- 2014/02/20 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/20 06:00
PHST- 2013/12/18 00:00 [received]
PHST- 2014/01/22 00:00 [revised]
PHST- 2014/02/06 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0304-3940(14)00108-6 [pii]
AID - 10.1016/j.neulet.2014.02.013 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Apr 3;564:78-82. doi: 10.1016/j.neulet.2014.02.013. Epub 2014 
      Feb 16.