PMID- 24548738
OWN - NLM
STAT- MEDLINE
DCOM- 20160413
LR  - 20140619
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 68
IP  - 7
DP  - 2014 Jul
TI  - Risk factors associated with retinal vein occlusion.
PG  - 871-81
LID - 10.1111/ijcp.12390 [doi]
AB  - AIMS: Retinal vein occlusion (RVO) is the most frequent retinal vascular disease 
      after diabetic retinopathy in which arterial risk factors are much more relevant 
      than venous factors. The objective was to evaluate the role of risk factors in 
      the development of the first episode of RVO. SUBJECTS AND METHODS: One hundred 
      patients with RVO [mean age 56 years, 42% females and mean body mass index (BMI) 
      27.5 kg/m(2)] were recruited consecutively from the outpatient clinic of a 
      tertiary hospital in Valencia (Spain). All subjects underwent clinical assessment 
      including anthropometric and blood pressure measurements and laboratory test 
      including homocysteine, antiphospholipid antibodies (aPLAs) and thrombophilia 
      studies. In half of the subjects, a carotid ultrasonography was performed. Three 
      control populations matched by age, sex and BMI from different population-based 
      studies were used to compare the levels and prevalence of arterial risk factors. 
      One cohort of young patients with venous thromboembolic disease was used to 
      compare the venous risk factors. RESULTS: Blood pressure levels and the 
      prevalence of hypertension were significantly higher in the RVO population when 
      compared with those for the general populations. There was also a large 
      proportion of undiagnosed hypertension within the RVO group. Moreover, carotid 
      evaluation revealed that a large proportion of patients with RVO had evidence of 
      subclinical organ damage. In addition, homocysteine levels and prevalence of 
      aPLAs were similar to the results obtained in our cohort of venous thromboembolic 
      disease. CONCLUSIONS: The results indicate that hypertension is the key factor in 
      the development of RVO, and that RVO can be the first manifestation of an 
      undiagnosed hypertension. Furthermore, the majority of these patients had 
      evidence of atherosclerotic disease. Among the venous factors, a thrombophilia 
      study does not seem to be useful and only the prevalence of hyperhomocysteinaemia 
      and aPLAs is higher than in the general population.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Martinez, F
AU  - Martinez F
AD  - Internal Medicine Department, Fundacion de Investigacion del Hospital Clinico de 
      Valencia- INCLIVA, Hospital Clinico Universitario, Universidad de Valencia, 
      Valencia, Spain; "Centro de Investigacion Biomedica en Red (CIBER) de 
      Fisiopatologia, Obesidad y Nutricion (CIBEROB)", Institute of Health Carlos III, 
      Minister of Health, Madrid, Spain.
FAU - Furio, E
AU  - Furio E
FAU - Fabia, M J
AU  - Fabia MJ
FAU - Perez, A V
AU  - Perez AV
FAU - Gonzalez-Albert, V
AU  - Gonzalez-Albert V
FAU - Rojo-Martinez, G
AU  - Rojo-Martinez G
FAU - Martinez-Larrad, M T
AU  - Martinez-Larrad MT
FAU - Mena-Martin, F J
AU  - Mena-Martin FJ
FAU - Soriguer, F
AU  - Soriguer F
FAU - Serrano-Rios, M
AU  - Serrano-Rios M
FAU - Chaves, F J
AU  - Chaves FJ
FAU - Martin-Escudero, J C
AU  - Martin-Escudero JC
FAU - Redon, J
AU  - Redon J
FAU - Garcia-Fuster, M J
AU  - Garcia-Fuster MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140218
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
SB  - IM
MH  - Adult
MH  - Aged
MH  - Dyslipidemias/complications
MH  - Female
MH  - Humans
MH  - Hypertension/complications
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications
MH  - *Prevalence
MH  - Retinal Vein Occlusion/*epidemiology/etiology
MH  - Risk Factors
MH  - Spain
MH  - Thrombophilia/complications
EDAT- 2014/02/20 06:00
MHDA- 2016/04/14 06:00
CRDT- 2014/02/20 06:00
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - 10.1111/ijcp.12390 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2014 Jul;68(7):871-81. doi: 10.1111/ijcp.12390. Epub 2014 Feb 
      18.