PMID- 24548878
OWN - NLM
STAT- MEDLINE
DCOM- 20150306
LR  - 20240214
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 4
IP  - 2
DP  - 2014 Feb 18
TI  - Long-term effects of maternal immune activation on depression-like behavior in 
      the mouse.
PG  - e363
LID - 10.1038/tp.2013.132 [doi]
AB  - Depression is a debilitating mental disease affecting a large population 
      worldwide, the pathophysiological mechanisms of which remain incompletely 
      understood. Prenatal infection and associated activation of the maternal immune 
      system (MIA) are prominently related to an increased risk for the development of 
      several psychiatric disorders including schizophrenia and autism in the 
      offsprings. However, the role of MIA in the etiology of depression and its 
      neurobiological basis are insufficiently investigated. Here we induced MIA in 
      mice by challenge with polyinosinic:polycytidylic phosphate salt-a synthetic 
      analog of double-stranded RNA, which enhances maternal levels of the cytokine 
      interleukin-6 (IL-6)-and demonstrate a depression-like behavioral phenotype in 
      adult offsprings. Adult offsprings additionally show deficits in cognition and 
      hippocampal long-term potentiation (LTP) accompanied by disturbed proliferation 
      of newborn cells in the dentate gyrus and compromised neuronal maturation and 
      survival. The behavioral, neurogenic and functional deficiencies observed are 
      associated with reduced hippocampal expression of vascular endothelial growth 
      factor (VEGF)A-VEGFR2. IL-6-STAT3-dependent aberrant VEGFA-VEGFR2 signaling is 
      proposed as neurobiological mechanism mediating the effects of MIA on the 
      developing fetal brain and ensuing consequences in adulthood.
FAU - Khan, D
AU  - Khan D
AD  - Department of Neurophysiology and Neuropharmacology, Center for Physiology and 
      Pharmacology, Medical University of Vienna, Vienna, Austria.
FAU - Fernando, P
AU  - Fernando P
AD  - Department of Neurophysiology and Neuropharmacology, Center for Physiology and 
      Pharmacology, Medical University of Vienna, Vienna, Austria.
FAU - Cicvaric, A
AU  - Cicvaric A
AD  - Department of Neurophysiology and Neuropharmacology, Center for Physiology and 
      Pharmacology, Medical University of Vienna, Vienna, Austria.
FAU - Berger, A
AU  - Berger A
AD  - Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 
      Vienna, Austria.
FAU - Pollak, A
AU  - Pollak A
AD  - Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 
      Vienna, Austria.
FAU - Monje, F J
AU  - Monje FJ
AD  - Department of Neurophysiology and Neuropharmacology, Center for Physiology and 
      Pharmacology, Medical University of Vienna, Vienna, Austria.
FAU - Pollak, D D
AU  - Pollak DD
AD  - Department of Neurophysiology and Neuropharmacology, Center for Physiology and 
      Pharmacology, Medical University of Vienna, Vienna, Austria.
LA  - eng
GR  - P 22424/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140218
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Cognition Disorders/*etiology
MH  - Depression/*etiology
MH  - Disease Models, Animal
MH  - Female
MH  - Hippocampus/metabolism/*physiopathology
MH  - Interleukin-6/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*immunology
MH  - Receptors, Vascular Endothelial Growth Factor/metabolism
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC3944633
EDAT- 2014/02/20 06:00
MHDA- 2015/03/07 06:00
PMCR- 2014/02/01
CRDT- 2014/02/20 06:00
PHST- 2013/10/16 00:00 [received]
PHST- 2013/11/29 00:00 [revised]
PHST- 2013/12/07 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - tp2013132 [pii]
AID - 10.1038/tp.2013.132 [doi]
PST - epublish
SO  - Transl Psychiatry. 2014 Feb 18;4(2):e363. doi: 10.1038/tp.2013.132.