PMID- 24549103
OWN - NLM
STAT- MEDLINE
DCOM- 20141229
LR  - 20240502
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 39
IP  - 7
DP  - 2014 Jun
TI  - Resting brain activity varies with dream recall frequency between subjects.
PG  - 1594-602
LID - 10.1038/npp.2014.6 [doi]
AB  - Dreaming is still poorly understood. Notably, its cerebral underpinning remains 
      unclear. Neuropsychological studies have shown that lesions in the 
      temporoparietal junction (TPJ) and/or the white matter of the medial prefrontal 
      cortex (MPFC) lead to the global cessation of dream reports, suggesting that 
      these regions of the default mode network have key roles in the dreaming process 
      (forebrain 'dream-on' hypothesis). To test this hypothesis, we measured regional 
      cerebral blood flow (rCBF) using [(15)O]H2O positron emission tomography in 
      healthy subjects with high and low dream recall frequencies (DRFs) during 
      wakefulness (rest) and sleep (rapid eye movement (REM) sleep, N2, and N3). 
      Compared with Low recallers (0.5 +/- 0.3 dream recall per week in average), High 
      recallers (5.2 +/- 1.4) showed higher rCBF in the TPJ during REM sleep, N3, and 
      wakefulness, and in the MPFC during REM sleep and wakefulness. We demonstrate 
      that the resting states of High recallers and Low recallers differ during sleep 
      and wakefulness. It coheres with previous ERP results and confirms that a 
      high/low DRF is associated with a specific functional organization of the brain. 
      These results support the forebrain 'dream-on' hypothesis and suggest that TPJ 
      and MPFC are not only involved in dream recall during wakefulness but also have a 
      role in dreaming during sleep (production and/or encoding). Increased activity in 
      the TPJ and MPFC might promote the mental imagery and/or memory encoding of 
      dreams. Notably, increased activity in TPJ might facilitate attention orienting 
      toward external stimuli and promote intrasleep wakefulness, facilitating the 
      encoding of the dreams in memory.
FAU - Eichenlaub, Jean-Baptiste
AU  - Eichenlaub JB
AD  - 1] CRNL-Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Brain 
      Dynamics and Cognition Team, Centre Hospitalier Le Vinatier (Bat. 452), Lyon, 
      France [2] University Claude Bernard Lyon 1, Lyon, France.
FAU - Nicolas, Alain
AU  - Nicolas A
AD  - Unite d'Exploration Hypnologique, Centre Hospitalier Le Vinatier, Lyon, France.
FAU - Daltrozzo, Jerome
AU  - Daltrozzo J
AD  - 1] CRNL-Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Brain 
      Dynamics and Cognition Team, Centre Hospitalier Le Vinatier (Bat. 452), Lyon, 
      France [2] University Claude Bernard Lyon 1, Lyon, France.
FAU - Redoute, Jerome
AU  - Redoute J
AD  - CERMEP-Imagerie du Vivant, Lyon, France.
FAU - Costes, Nicolas
AU  - Costes N
AD  - CERMEP-Imagerie du Vivant, Lyon, France.
FAU - Ruby, Perrine
AU  - Ruby P
AD  - 1] CRNL-Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Brain 
      Dynamics and Cognition Team, Centre Hospitalier Le Vinatier (Bat. 452), Lyon, 
      France [2] University Claude Bernard Lyon 1, Lyon, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140116
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Oxygen Radioisotopes)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Attention/physiology
MH  - Brain/diagnostic imaging/*physiology
MH  - Cerebrovascular Circulation/*physiology
MH  - *Dreams
MH  - Electroencephalography
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Recall/*physiology
MH  - Oxygen Radioisotopes
MH  - Photic Stimulation
MH  - Positron-Emission Tomography
MH  - Rest/*physiology
MH  - Sleep/physiology
MH  - Wakefulness/physiology
MH  - Young Adult
PMC - PMC4023156
EDAT- 2014/02/20 06:00
MHDA- 2014/12/30 06:00
PMCR- 2015/06/01
CRDT- 2014/02/20 06:00
PHST- 2013/02/28 00:00 [received]
PHST- 2014/01/08 00:00 [revised]
PHST- 2014/01/09 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - npp20146 [pii]
AID - 10.1038/npp.2014.6 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2014 Jun;39(7):1594-602. doi: 10.1038/npp.2014.6. Epub 
      2014 Jan 16.