PMID- 24549184
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20211021
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 34
IP  - 5
DP  - 2014 May
TI  - Intermittent fasting attenuates increases in neurogenesis after ischemia and 
      reperfusion and improves recovery.
PG  - 897-905
LID - 10.1038/jcbfm.2014.36 [doi]
AB  - Intermittent fasting (IF) is neuroprotective across a range of insults, but the 
      question of whether extending the interval between meals alters neurogenesis 
      after ischemia remains unexplored. We therefore measured cell proliferation, cell 
      death, and neurogenesis after transient middle cerebral artery occlusion (MCAO) 
      or sham surgery (SHAM) in mice fed ad libitum (AL) or maintained on IF for 3 
      months. IF was associated with twofold reductions in circulating levels of the 
      adipocyte cytokine leptin in intact mice, but also prevented further reductions 
      in leptin after MCAO. IF/MCAO mice also exhibit infarct volumes that were less 
      than half those of AL/MCAO mice. We observed a 30% increase in basal cell 
      proliferation in the hippocampus and subventricular zone (SVZ) in IF/SHAM, 
      relative to AL/SHAM mice. However, cell proliferation after MCAO was limited in 
      IF mice, which showed twofold increases in cell proliferation relative to 
      IF/SHAM, whereas AL/MCAO mice exhibit fivefold increases relative to AL/SHAM. 
      Attenuation of stroke-induced neurogenesis was correlated with reductions in cell 
      death, with AL/MCAO mice exhibiting twice the number of dying cells relative to 
      IF/MCAO mice. These observations indicate that IF protects against neurological 
      damage in ischemic stroke, with circulating leptin as one possible mediator.
FAU - Manzanero, Silvia
AU  - Manzanero S
AD  - School of Biomedical Sciences, The University of Queensland, St Lucia, 
      Queensland, Australia.
FAU - Erion, Joanna R
AU  - Erion JR
AD  - Department of Physiology, Georgia Regents University, Augusta, Georgia, USA.
FAU - Santro, Tomislav
AU  - Santro T
AD  - School of Biomedical Sciences, The University of Queensland, St Lucia, 
      Queensland, Australia.
FAU - Steyn, Frederik J
AU  - Steyn FJ
AD  - School of Biomedical Sciences, The University of Queensland, St Lucia, 
      Queensland, Australia.
FAU - Chen, Chen
AU  - Chen C
AD  - School of Biomedical Sciences, The University of Queensland, St Lucia, 
      Queensland, Australia.
FAU - Arumugam, Thiruma V
AU  - Arumugam TV
AD  - School of Biomedical Sciences, The University of Queensland, St Lucia, 
      Queensland, Australia.
FAU - Stranahan, Alexis M
AU  - Stranahan AM
AD  - Department of Physiology, Georgia Regents University, Augusta, Georgia, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140219
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Leptin)
SB  - IM
MH  - Animals
MH  - Cell Death
MH  - Cell Proliferation
MH  - Fasting/*physiology
MH  - Hippocampus/blood supply/pathology/*physiopathology
MH  - Infarction, Middle Cerebral Artery/blood/pathology/*physiopathology
MH  - Leptin/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Neurogenesis
MH  - Neurons/cytology/*pathology
MH  - Weight Loss
PMC - PMC4013772
EDAT- 2014/02/20 06:00
MHDA- 2014/06/18 06:00
PMCR- 2015/05/01
CRDT- 2014/02/20 06:00
PHST- 2013/11/21 00:00 [received]
PHST- 2014/01/22 00:00 [revised]
PHST- 2014/01/24 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - jcbfm201436 [pii]
AID - 10.1038/jcbfm.2014.36 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2014 May;34(5):897-905. doi: 10.1038/jcbfm.2014.36. 
      Epub 2014 Feb 19.