PMID- 2454970
OWN - NLM
STAT- MEDLINE
DCOM- 19880808
LR  - 20151119
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 271
IP  - 4
DP  - 1988 May 22
TI  - Frontal eye field efferents in the macaque monkey: I. Subcortical pathways and 
      topography of striatal and thalamic terminal fields.
PG  - 473-92
AB  - Anterograde tracers (tritiated leucine, proline, fucose; WGA-HRP) were injected 
      into sites within the frontal eye fields (FEF) of nine macaque monkeys. Low 
      thresholds (less than or equal to 50 microA) for electrically evoking saccadic 
      eye movements were used to locate injection sites in four monkeys. Cases were 
      grouped according to the amplitude of saccades evoked or predicted at the 
      injection site. Dorsomedial prearcuate injection sites where large saccades were 
      elicited were classified as lFEF cases, whereas ventrolateral prearcuate sites 
      where small saccades were evoked were designated sFEF cases. One control case was 
      injected in the medial postarcuate area 6. We found five descending fiber bundles 
      from FEF; fibers to the striatum, which enter the caudate nucleus at or just 
      rostral to the genu of the internal capsule; fibers to the claustrum, which 
      travel in the external capsule; and transthalamic, subthalamic, and 
      pedunculopontine fibers. Our results indicate that transthalamic and subthalamic 
      pathways supply all terminal sites in the thalamus, subthalamus, and tegmentum of 
      the midbrain and pons, whereas pedunculopontine fibers appear to terminate in the 
      pontine and reticularis tegmenti pontis nucleus exclusively. Frontal eye field 
      terminal fields in the striatum were topographically organized: lFEF projections 
      terminated dorsal and rostral to sFEF projections. Thus, lFEF terminal fields 
      were located centrally in the head and body of the caudate nucleus and a small 
      dorsomedial portion of the putamen, whereas sFEF terminal fields were located in 
      ventrolateral parts of the caudate body and ventromedial parts of the putamen. In 
      the claustrum, lFEF projections terminated dorsal and rostral to sFEF 
      projections. Projections from FEF terminated in ventral and caudal parts of the 
      subthalamic nucleus without a clear topography. By comparison, terminal fields 
      from medial postarcuate area 6 were located more caudally and laterally in the 
      striatum and claustrum than projections from FEF, and more centrally in the 
      subthalamic nucleus. In the thalamus, FEF terminal patches in some thalamic 
      nuclei were also topographically organized. Projections from lFEF terminated in 
      dorsal area X, dorsolateral medial dorsal nucleus, pars parvicellularis (MDpc), 
      and the caudal pole of MDpc, whereas projections from sFEF terminated in ventral 
      area X, medial dorsal nucleus, pars multiformis, and caudal medial dorsal nucleus 
      pars densocellularis.(ABSTRACT TRUNCATED AT 400 WORDS)
FAU - Stanton, G B
AU  - Stanton GB
AD  - Department of Anatomy, Howard University College of Medicine, Washington, DC 
      20059.
FAU - Goldberg, M E
AU  - Goldberg ME
FAU - Bruce, C J
AU  - Bruce CJ
LA  - eng
GR  - EY 03763/EY/NEI NIH HHS/United States
GR  - EY 04740/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Amino Acids)
RN  - 0 (Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate)
RN  - 0 (Wheat Germ Agglutinins)
RN  - EC 1.11.1.- (Horseradish Peroxidase)
SB  - IM
MH  - Amino Acids
MH  - Animals
MH  - Autoradiography
MH  - Brain Mapping
MH  - Corpus Striatum/*anatomy & histology/physiology
MH  - Efferent Pathways/anatomy & histology
MH  - Electric Stimulation
MH  - *Eye Movements
MH  - Horseradish Peroxidase
MH  - Macaca/*anatomy & histology/physiology
MH  - Macaca fascicularis
MH  - Macaca mulatta
MH  - Oculomotor Muscles/*innervation/physiology
MH  - Thalamus/*anatomy & histology/physiology
MH  - Visual Fields
MH  - Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
MH  - Wheat Germ Agglutinins
EDAT- 1988/05/22 00:00
MHDA- 1988/05/22 00:01
CRDT- 1988/05/22 00:00
PHST- 1988/05/22 00:00 [pubmed]
PHST- 1988/05/22 00:01 [medline]
PHST- 1988/05/22 00:00 [entrez]
AID - 10.1002/cne.902710402 [doi]
PST - ppublish
SO  - J Comp Neurol. 1988 May 22;271(4):473-92. doi: 10.1002/cne.902710402.