PMID- 24550703
OWN - NLM
STAT- MEDLINE
DCOM- 20141228
LR  - 20211021
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2014
DP  - 2014
TI  - Enhancement of BDNF concentration and restoration of the 
      hypothalamic-pituitary-adrenal axis accompany reduced depressive-like behaviour 
      in stressed ovariectomised rats treated with either Tualang honey or estrogen.
PG  - 310821
LID - 10.1155/2014/310821 [doi]
LID - 310821
AB  - A possible interaction between glucocorticoids and estrogen-induced increases in 
      brain-derived-neurotrophic factor (BDNF) expression in enhancing depressive-like 
      behaviour has been documented. Here we evaluated the effects of Tualang honey, a 
      phytoestrogen, and 17 beta -estradiol (E2) on the depressive-like behaviour, stress 
      hormones, and BDNF concentration in stressed ovariectomised (OVX) rats. The 
      animals were divided into six groups: (i) nonstressed sham-operated control, (ii) 
      stressed sham-operated control, (iii) nonstressed OVX, (iv) stressed OVX, (v) 
      stressed OVX treated with E2 (20  mug daily, sc), and (vi) stressed OVX treated 
      with Tualang honey (0.2 g/kg body weight daily, orally). Two months after 
      surgery, the animals were subjected to social instability stress procedure 
      followed by forced swimming test. Struggling time, immobility time, and swimming 
      time were scored. Serum adrenocorticotropic hormone (ACTH) and corticosterone 
      levels, and the BDNF concentration were determined using commercially available 
      ELISA kits. Stressed OVX rats displayed increased depressive-like behaviour with 
      significantly increased serum ACTH and corticosterone levels, while the BDNF 
      concentration was significantly decreased compared to other experimental groups. 
      These changes were notably reversed by both E2 and Tualang honey. In conclusion, 
      both Tualang honey and E2 mediate antidepressive-like effects in stressed OVX 
      rats, possibly acting via restoration of hypothalamic-pituitary-adrenal axis and 
      enhancement of the BDNF concentration.
FAU - Al-Rahbi, Badriya
AU  - Al-Rahbi B
AD  - Institute of Health Sciences, Muscat P.O. Box 3720, Ruwi Code 112, Oman.
FAU - Zakaria, Rahimah
AU  - Zakaria R
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150 Kubang Kerian, Kelantan, Malaysia.
FAU - Othman, Zahiruddin
AU  - Othman Z
AUID- ORCID: 0000-0002-9070-2078
AD  - Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, 
      16150 Kubang Kerian, Kelantan, Malaysia.
FAU - Hassan, Asma'
AU  - Hassan A
AD  - Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia, 
      16150 Kubang Kerian, Kelantan, Malaysia.
FAU - Ahmad, Asma Hayati
AU  - Ahmad AH
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150 Kubang Kerian, Kelantan, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140116
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogens)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Behavior, Animal
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/blood
MH  - Depression/drug therapy/*metabolism
MH  - Estrogens/administration & dosage/*pharmacology
MH  - Female
MH  - *Honey
MH  - Hypothalamo-Hypophyseal System/*physiology
MH  - Ovariectomy
MH  - Pituitary-Adrenal System/*physiology
MH  - Rats
MH  - Stress, Physiological
PMC - PMC3914545
EDAT- 2014/02/20 06:00
MHDA- 2014/12/30 06:00
PMCR- 2014/01/16
CRDT- 2014/02/20 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2013/10/28 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
PHST- 2014/01/16 00:00 [pmc-release]
AID - 10.1155/2014/310821 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2014 Jan 16;2014:310821. doi: 10.1155/2014/310821. 
      eCollection 2014.