PMID- 24550791
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140219
LR  - 20220410
IS  - 1662-5137 (Print)
IS  - 1662-5137 (Electronic)
IS  - 1662-5137 (Linking)
VI  - 8
DP  - 2014
TI  - The effect of mild-to-moderate hearing loss on auditory and emotion processing 
      networks.
PG  - 10
LID - 10.3389/fnsys.2014.00010 [doi]
LID - 10
AB  - We investigated the impact of hearing loss (HL) on emotional processing using 
      task- and rest-based functional magnetic resonance imaging. Two age-matched 
      groups of middle-aged participants were recruited: one with bilateral 
      high-frequency HL and a control group with normal hearing (NH). During the 
      task-based portion of the experiment, participants were instructed to rate 
      affective stimuli from the International Affective Digital Sounds (IADS) database 
      as pleasant, unpleasant, or neutral. In the resting state experiment, 
      participants were told to fixate on a "+" sign on a screen for 5 min. The results 
      of both the task-based and resting state studies suggest that NH and HL patients 
      differ in their emotional response. Specifically, in the task-based study, we 
      found slower response to affective but not neutral sounds by the HL group 
      compared to the NH group. This was reflected in the brain activation patterns, 
      with the NH group employing the expected limbic and auditory regions including 
      the left amygdala, left parahippocampus, right middle temporal gyrus and left 
      superior temporal gyrus to a greater extent in processing affective stimuli when 
      compared to the HL group. In the resting state study, we observed no significant 
      differences in connectivity of the auditory network between the groups. In the 
      dorsal attention network (DAN), HL patients exhibited decreased connectivity 
      between seed regions and left insula and left postcentral gyrus compared to 
      controls. The default mode network (DMN) was also altered, showing increased 
      connectivity between seeds and left middle frontal gyrus in the HL group. Further 
      targeted analysis revealed increased intrinsic connectivity between the right 
      middle temporal gyrus and the right precentral gyrus. The results from both 
      studies suggest neuronal reorganization as a consequence of HL, most notably in 
      networks responding to emotional sounds.
FAU - Husain, Fatima T
AU  - Husain FT
AD  - Department of Speech and Hearing Science, University of Illinois at 
      Urbana-Champaign Champaign, IL, USA ; The Neuroscience Program, University of 
      Illinois at Urbana-Champaign Champaign, IL, USA ; Beckman Institute for Advanced 
      Science and Technology, University of Illinois at Urbana-Champaign Champaign, IL, 
      USA.
FAU - Carpenter-Thompson, Jake R
AU  - Carpenter-Thompson JR
AD  - The Neuroscience Program, University of Illinois at Urbana-Champaign Champaign, 
      IL, USA ; Beckman Institute for Advanced Science and Technology, University of 
      Illinois at Urbana-Champaign Champaign, IL, USA.
FAU - Schmidt, Sara A
AU  - Schmidt SA
AD  - The Neuroscience Program, University of Illinois at Urbana-Champaign Champaign, 
      IL, USA ; Beckman Institute for Advanced Science and Technology, University of 
      Illinois at Urbana-Champaign Champaign, IL, USA.
LA  - eng
PT  - Journal Article
DEP - 20140204
PL  - Switzerland
TA  - Front Syst Neurosci
JT  - Frontiers in systems neuroscience
JID - 101477946
PMC - PMC3912518
OTO - NOTNLM
OT  - IADS
OT  - emotion
OT  - fMRI
OT  - functional connectivity
OT  - hearing loss
OT  - resting-state fMRI
EDAT- 2014/02/20 06:00
MHDA- 2014/02/20 06:01
PMCR- 2014/01/01
CRDT- 2014/02/20 06:00
PHST- 2013/08/15 00:00 [received]
PHST- 2014/01/15 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/02/20 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnsys.2014.00010 [doi]
PST - epublish
SO  - Front Syst Neurosci. 2014 Feb 4;8:10. doi: 10.3389/fnsys.2014.00010. eCollection 
      2014.