PMID- 24550802
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140219
LR  - 20211021
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 8
DP  - 2014
TI  - Social instability stress differentially affects amygdalar neuron adaptations and 
      memory performance in adolescent and adult rats.
PG  - 27
LID - 10.3389/fnbeh.2014.00027 [doi]
LID - 27
AB  - Adolescence is a time of developmental changes and reorganization in the brain. 
      It has been hypothesized that stress has a greater neurological impact on 
      adolescents than on adults. However, scientific evidence in support of this 
      hypothesis is still limited. We treated adolescent (4-week-old) and adult 
      (8-week-old) rats with social instability stress for 5 weeks and compared the 
      subsequent structural and functional changes to amygdala neurons. In the 
      stress-free control condition, the adolescent group showed higher 
      fear-potentiated startle responses, larger dendritic arborization, more proximal 
      dendritic spine distribution and lower levels of truncated TrkB than the adult 
      rats. Social instability stress exerted opposite effects on fear-potentiated 
      startle responses in these two groups, i.e., the stress period appeared to hamper 
      the performance in adolescents but improved it in adult rats. Furthermore, whilst 
      the chronic social stress applied to adolescent rats reduced their dendritic 
      field and spine density in basal and lateral amygdala neurons, the opposite 
      stress effects on neuron morphology were observed in the adult rats. Moreover, 
      stress in adolescence suppressed the amygdala expression of synaptic proteins, 
      i.e., full-length TrkB and SNAP-25, whereas, in the adult rats, chronic stress 
      enhanced full-length and truncated TrkB expressions in the amygdala. In summary, 
      chronic social instability stress hinders amygdala neuron development in the 
      adolescent brain, while mature neurons in the amygdala are capable of adapting to 
      the stress. The stress induced age-dependent effects on the fear-potentiated 
      memory may occur by altering the brain-derived neurotrophic factor (BDNF)-TrkB 
      signaling and neuroplasticity in the amygdala.
FAU - Tsai, Sheng-Feng
AU  - Tsai SF
AD  - Department of Physiology, National Cheng Kung University Tainan, Taiwan ; 
      Institute of Basic Medical Sciences, National Cheng Kung University Tainan, 
      Taiwan.
FAU - Huang, Tung-Yi
AU  - Huang TY
AD  - Department of Physiology, National Cheng Kung University Tainan, Taiwan.
FAU - Chang, Chia-Yuan
AU  - Chang CY
AD  - Department of Engineering Science, National Cheng Kung University Tainan, Taiwan 
      ; Advanced Optoelectronic Technology Center, National Cheng Kung University 
      Tainan, Taiwan.
FAU - Hsu, Yuan-Chang
AU  - Hsu YC
AD  - Institute of Basic Medical Sciences, National Cheng Kung University Tainan, 
      Taiwan.
FAU - Chen, Shean-Jen
AU  - Chen SJ
AD  - Department of Engineering Science, National Cheng Kung University Tainan, Taiwan 
      ; Advanced Optoelectronic Technology Center, National Cheng Kung University 
      Tainan, Taiwan.
FAU - Yu, Lung
AU  - Yu L
AD  - Institute of Basic Medical Sciences, National Cheng Kung University Tainan, 
      Taiwan ; Institute of Behavioral Medicine, National Cheng Kung University Tainan, 
      Taiwan.
FAU - Kuo, Yu-Min
AU  - Kuo YM
AD  - Institute of Basic Medical Sciences, National Cheng Kung University Tainan, 
      Taiwan ; Department of Cell Biology and Anatomy, National Cheng Kung University 
      Tainan, Taiwan.
FAU - Jen, Chauying J
AU  - Jen CJ
AD  - Department of Physiology, National Cheng Kung University Tainan, Taiwan ; 
      Institute of Basic Medical Sciences, National Cheng Kung University Tainan, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20140203
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC3909871
OTO - NOTNLM
OT  - TrkB
OT  - adolescent
OT  - dendritic spine
OT  - memory
OT  - neuroplasticity
EDAT- 2014/02/20 06:00
MHDA- 2014/02/20 06:01
PMCR- 2014/01/01
CRDT- 2014/02/20 06:00
PHST- 2013/11/22 00:00 [received]
PHST- 2014/01/19 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/02/20 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2014.00027 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2014 Feb 3;8:27. doi: 10.3389/fnbeh.2014.00027. eCollection 
      2014.