PMID- 24551075
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - A longitudinal study of alterations of hippocampal volumes and serum BDNF levels 
      in association to atypical antipsychotics in a sample of first-episode patients 
      with schizophrenia.
PG  - e87997
LID - 10.1371/journal.pone.0087997 [doi]
LID - e87997
AB  - BACKGROUND: Schizophrenia is associated with structural and functional 
      abnormalities of the hippocampus, which have been suggested to play an important 
      role in the formation and emergence of schizophrenia syndrome. Patients with 
      schizophrenia exhibit significant bilateral hippocampal volume reduction and 
      progressive hippocampal volume decrease in first-episode patients with 
      schizophrenia has been shown in many neuroimaging studies. Dysfunction of the 
      neurotrophic system has been implicated in the pathophysiology of schizophrenia. 
      The initiation of antipsychotic medication alters the levels of serum Brain 
      Derived Neurotrophic Factor (BDNF) levels. However it is unclear whether 
      treatment with antipsychotics is associated with alterations of hippocampal 
      volume and BDNF levels. METHODS: In the present longitudinal study we 
      investigated the association between serum BDNF levels and hippocampal volumes in 
      a sample of fourteen first-episode drug-naive patients with schizophrenia (FEP). 
      MRI scans, BDNF and clinical measurements were performed twice: at baseline 
      before the initiation of antipsychotic treatment and 8 months later, while the 
      patients were receiving monotherapy with second generation antipsychotics (SGAs). 
      RESULTS: We found that left hippocampal volume was decreased (corrected left HV 
      [t = 2.977, df = 13, p = .011] at follow-up; We also found that the higher the 
      BDNF levels change the higher were the differences of corrected left hippocampus 
      after 8 months of treatment with atypical antipsychotics (Pearson r = 0.597, p = 
      0.024). CONCLUSIONS: The association of BDNF with hippocampal volume alterations 
      in schizophrenia merits further investigation and replication in larger 
      longitudinal studies.
FAU - Rizos, Emmanouil
AU  - Rizos E
AD  - 2nd Department of Psychiatry, "ATTIKON" General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Papathanasiou, Matilda A
AU  - Papathanasiou MA
AD  - 2nd Department of Radiology, "ATTIKON" General Hospital, Medical School, National 
      and Kapodistrian University of Athens, Athens, Greece.
FAU - Michalopoulou, Panagiota G
AU  - Michalopoulou PG
AD  - 2nd Department of Psychiatry, "ATTIKON" General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece ; Department of 
      Psychosis Studies, Section on Schizophrenia, Imaging and Therapeutics, Institute 
      of Psychiatry, King's College London, London, United Kingdom.
FAU - Laskos, Efstathios
AU  - Laskos E
AD  - Biochemistry and Microbiology Department, Athens Psychiatric Hospital 
      "Dromokaition", Athens, Greece.
FAU - Mazioti, Aggeliki
AU  - Mazioti A
AD  - 2nd Department of Radiology, "ATTIKON" General Hospital, Medical School, National 
      and Kapodistrian University of Athens, Athens, Greece.
FAU - Kastania, Anastasia
AU  - Kastania A
AD  - Department of Informatics, Athens University of Economics and Business, Athens, 
      Greece.
FAU - Vasilopoulou, Konstantina
AU  - Vasilopoulou K
AD  - 2nd Department of Psychiatry, "ATTIKON" General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Nikolaidou, Paraskevi
AU  - Nikolaidou P
AD  - 2nd Department of Psychiatry, "ATTIKON" General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Margaritis, Dimitrios
AU  - Margaritis D
AD  - 2nd Department of Psychiatry, "ATTIKON" General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Papageorgiou, Charalabos
AU  - Papageorgiou C
AD  - 2nd Department of Psychiatry, "ATTIKON" General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Liappas, Ioannis
AU  - Liappas I
AD  - 2nd Department of Psychiatry, "ATTIKON" General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20140213
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Female
MH  - Gene Expression
MH  - Hippocampus/drug effects/metabolism/*pathology
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Schizophrenia/blood/drug therapy/*pathology
PMC - PMC3923760
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/02/20 06:00
MHDA- 2014/10/15 06:00
PMCR- 2014/02/13
CRDT- 2014/02/20 06:00
PHST- 2013/09/11 00:00 [received]
PHST- 2014/01/03 00:00 [accepted]
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
PHST- 2014/02/13 00:00 [pmc-release]
AID - PONE-D-13-37350 [pii]
AID - 10.1371/journal.pone.0087997 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 13;9(2):e87997. doi: 10.1371/journal.pone.0087997. eCollection 
      2014.