PMID- 24551772
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140219
LR  - 20211021
IS  - 2251-9637 (Print)
IS  - 2251-9645 (Electronic)
IS  - 2251-9637 (Linking)
VI  - 1
IP  - 3
DP  - 2012 Summer
TI  - Hematologic features of alpha thalassemia carriers.
PG  - 162-7
AB  - Alpha thalassemia (alpha-thal) is relatively common worldwide. Most carriers are 
      defective in either one or two alpha globin genes out of four functional ones, 
      with deletions being more common than point mutations. The hematologic features 
      are very important for the selection of the appropriate molecular tests while 
      determining the genotype. The aim of this study was to compare hematologic 
      features of patients with various types of alpha globin mutations. Hematological 
      indices including red blood cells (RBC), hemoglobin concentration (Hb), mean cell 
      volume (MCV), mean cell hemoglobin (MCH), Mean corpuscular hemoglobin 
      concentration (MCHC) and percentage of Hemoglobin (HBA1, HBA2 and HBF) of 
      seven-hundred and twenty two patients presenting ten different alpha-thal genotypes 
      were considered. All patients showed reduced MCV and/or MCH values.Moreover, MCV 
      and MCH were lower in patients with two functional alpha globin genes in 
      comparison to patients with one mutated alpha globin gene (P value<0.001). In 
      conclusion, MCV and MCH valuescan be helpful for the selection of the appropriate 
      molecular tests to determine the genotype of alphathalassemia carriers.
FAU - Akhavan-Niaki, Haleh
AU  - Akhavan-Niaki H
AD  - Cellular and Molecular Biology Research Center (CMBRC), Babol University of 
      Medical Sciences, Babol, Iran. ; Genetic Laboratory of Amirkola Children 
      Hospital, Babol University of Medical Sciences, Babol, Iran.
FAU - Youssefi Kamangari, Reza
AU  - Youssefi Kamangari R
AD  - Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical 
      Sciences, Babol, Iran.
FAU - Banihashemi, Ali
AU  - Banihashemi A
AD  - Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical 
      Sciences, Babol, Iran.
FAU - Kholghi Oskooei, Vahid
AU  - Kholghi Oskooei V
AD  - Cellular and Molecular Biology Research Center (CMBRC), Babol University of 
      Medical Sciences, Babol, Iran.
FAU - Azizi, Mandana
AU  - Azizi M
AD  - Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical 
      Sciences, Babol, Iran.
FAU - Tamaddoni, Ahmad
AU  - Tamaddoni A
AD  - Non-Communicable Pediatric Diseases Research Center, Babol University of Medical 
      Sciences, Babol, Iran.
FAU - Sedaghat, Sadegh
AU  - Sedaghat S
AD  - Ayatollah Roohani Hospital, Babol University of Medical Sciences, Babol, Iran.
FAU - Vakili, Mohsen
AU  - Vakili M
AD  - Ayatollah Roohani Hospital, Babol University of Medical Sciences, Babol, Iran.
FAU - Mahmoudi Nesheli, Hassan
AU  - Mahmoudi Nesheli H
AD  - Non-Communicable Pediatric Diseases Research Center, Babol University of Medical 
      Sciences, Babol, Iran.
FAU - Shabani, Soraya
AU  - Shabani S
AD  - Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical 
      Sciences, Babol, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Mol Cell Med
JT  - International journal of molecular and cellular medicine
JID - 101598104
PMC - PMC3920506
OTO - NOTNLM
OT  - Alpha thalassemia
OT  - mean cell hemoglobin
OT  - mean cell volume
OT  - mutation
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
PMCR- 2012/06/01
CRDT- 2014/02/20 06:00
PHST- 2014/02/20 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - ijmcm-1-162 [pii]
PST - ppublish
SO  - Int J Mol Cell Med. 2012 Summer;1(3):162-7.