PMID- 2455231
OWN - NLM
STAT- MEDLINE
DCOM- 19880729
LR  - 20181130
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 333
IP  - 6176
DP  - 1988 Jun 30
TI  - Human basophil degranulation triggered by very dilute antiserum against IgE.
PG  - 816-8
AB  - When human polymorphonuclear basophils, a type of white blood cell with 
      antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to 
      anti-IgE antibodies, they release histamine from their intracellular granules and 
      change their staining properties. The latter can be demonstrated at dilutions of 
      anti-IgE that range from 1 x 10(2) to 1 x 10(120); over that range, there are 
      successive peaks of degranulation from 40 to 60% of the basophils, despite the 
      calculated absence of any anti-IgE molecules at the highest dilutions. Since 
      dilutions need to be accompanied by vigorous shaking for the effects to be 
      observed, transmission of the biological information could be related to the 
      molecular organization of water.
FAU - Davenas, E
AU  - Davenas E
AD  - INSERM U 200, Universite Paris-Sud, Clamart, France.
FAU - Beauvais, F
AU  - Beauvais F
FAU - Amara, J
AU  - Amara J
FAU - Oberbaum, M
AU  - Oberbaum M
FAU - Robinzon, B
AU  - Robinzon B
FAU - Miadonna, A
AU  - Miadonna A
FAU - Tedeschi, A
AU  - Tedeschi A
FAU - Pomeranz, B
AU  - Pomeranz B
FAU - Fortner, P
AU  - Fortner P
FAU - Belon, P
AU  - Belon P
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Receptors, Antigen, B-Cell)
RN  - 0 (anti-IgE antibodies)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*immunology
MH  - Basophils/*immunology/metabolism
MH  - *Histamine Release
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Osmolar Concentration
MH  - Receptors, Antigen, B-Cell/immunology
MH  - Research Design
EDAT- 1988/06/30 00:00
MHDA- 1988/06/30 00:01
CRDT- 1988/06/30 00:00
PHST- 1988/06/30 00:00 [pubmed]
PHST- 1988/06/30 00:01 [medline]
PHST- 1988/06/30 00:00 [entrez]
AID - 10.1038/333816a0 [doi]
PST - ppublish
SO  - Nature. 1988 Jun 30;333(6176):816-8. doi: 10.1038/333816a0.