PMID- 24552382
OWN - NLM
STAT- MEDLINE
DCOM- 20160520
LR  - 20140220
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 39
IP  - 3
DP  - 2014 Mar
TI  - Effects of a freeze-dried juice blend powder on exercise-induced inflammation, 
      oxidative stress, and immune function in cyclists.
PG  - 381-5
LID - 10.1139/apnm-2013-0338 [doi]
AB  - A freeze-dried fruit and vegetable juice powder (JUICE) was investigated as a 
      countermeasure nutritional strategy to exercise-induced inflammation, oxidative 
      stress, and immune perturbations in trained cyclists. Thirty-four cyclists (25 
      male, 9 female) were randomized to control (nonJUICE) or JUICE for 17 days. JUICE 
      provided 230 mg.day(-1) of flavonoids, doubling the typical adult daily intake. 
      During a 3-d period of intensified exercise (days 15-17), subjects cycled at 
      70%-75% V̇O2max for 2.25 h per day, followed by a 15-min time trial. Blood 
      samples were collected presupplementation, post supplementation (pre-exercise), 
      and immediately and 14-h post exercise on the third day of exercise. Samples were 
      analyzed for inflammation (interleukin (IL)-6, IL-8; tumor necrosis factor alpha 
      (TNFalpha); monocyte chemoattractant protein-1 (MCP-1)), oxidative stress (oxygen 
      radical absorbance capacity (ORAC), ferric reducing ability of plasma (FRAP), 
      reduced and oxidized glutathione, protein carbonyls), and innate immune function 
      (granulocyte (G-PHAG) and monocyte (M-PHAG) phagocytosis and oxidative burst 
      activity). A 2 (group) x 4 (time points) repeated measures ANOVA revealed 
      significant time effects due to 3 days of exercise for IL-6 (396% increase), IL-8 
      (78% increase), TNFalpha (12% increase), MCP-1 (30% increase), G-PHAG (38% increase), 
      M-PHAG (36% increase), FRAP (12.6% increase), ORAC (11% decrease at 14 h post 
      exercise), and protein carbonyls (82% increase at 14 h post exercise) (p < 0.01). 
      No significant interaction effects were found for any of the physiological 
      measures. Although providing 695 gallic acid equivalents of polyphenols per day, 
      JUICE treatment for 17 days did not change exercise-induced alterations in 
      inflammation and oxidative stress or immune function in trained cyclists after a 
      3-day period of overreaching.
FAU - Knab, Amy M
AU  - Knab AM
AD  - a Human Performance Laboratory, Appalachian State University, North Carolina 
      Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA.
FAU - Nieman, David C
AU  - Nieman DC
FAU - Gillitt, Nicholas D
AU  - Gillitt ND
FAU - Shanely, R Andrew
AU  - Shanely RA
FAU - Cialdella-Kam, Lynn
AU  - Cialdella-Kam L
FAU - Henson, Dru
AU  - Henson D
FAU - Sha, Wei
AU  - Sha W
FAU - Meaney, Mary Pat
AU  - Meaney MP
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20131022
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Flavonoids)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Adult
MH  - *Beverages
MH  - Bicycling/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Flavonoids/administration & dosage
MH  - Freezing
MH  - *Fruit
MH  - Humans
MH  - Inflammation/*immunology/*metabolism
MH  - Male
MH  - *Oxidative Stress
MH  - Polyphenols/administration & dosage
MH  - *Vegetables
EDAT- 2014/02/21 06:00
MHDA- 2016/05/21 06:00
CRDT- 2014/02/21 06:00
PHST- 2014/02/21 06:00 [entrez]
PHST- 2014/02/21 06:00 [pubmed]
PHST- 2016/05/21 06:00 [medline]
AID - 10.1139/apnm-2013-0338 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2014 Mar;39(3):381-5. doi: 10.1139/apnm-2013-0338. Epub 
      2013 Oct 22.