PMID- 24553197
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20220126
IS  - 1545-861X (Electronic)
IS  - 0149-2195 (Print)
IS  - 0149-2195 (Linking)
VI  - 63
IP  - 7
DP  - 2014 Feb 21
TI  - Influenza-associated intensive-care unit admissions and deaths - California, 
      September 29, 2013-January 18, 2014.
PG  - 143-7
AB  - The California Department of Public Health (CDPH) conducts surveillance on severe 
      influenza illness among California residents aged <65 years. Severe cases are 
      defined as those resulting in admission to an intensive care unit (ICU) or death; 
      reporting of ICU cases is voluntary, and reporting of fatal cases is mandatory. 
      This report describes the epidemiologic, laboratory, and clinical characteristics 
      of ICU and fatal influenza cases with symptom onset on or after September 29, 
      2013, and reported by January 18, 2014 of the 2013-14 influenza season. At the 
      time of this report, local health jurisdictions (LHJs) in California had reported 
      94 deaths and 311 ICU admissions of patients with a positive influenza test 
      result. The 405 reports of severe cases (i.e., fatal and ICU cases combined) were 
      more than in any season since the 2009 pandemic caused by the influenza A 
      (H1N1)pdm09 (pH1N1) virus. The pH1N1 virus is the predominant circulating 
      influenza virus this season. Of 405 ICU and fatal influenza cases, 266 (66%) 
      occurred among patients aged 41-64 years; 39 (10%) severe influenza illnesses 
      occurred among children aged <18 years. Only six (21%) of 28 patients with fatal 
      illness whose vaccination status was known had received 2013-14 seasonal 
      influenza vaccine >/=2 weeks before symptom onset. Of 80 patients who died for whom 
      sufficient information was available, 74 (93%) had underlying medical conditions 
      known to increase the risk for severe influenza, as defined by the Advisory 
      Committee on Immunization Practices (ACIP). Of 47 hospitalized patients with 
      fatal illness and known symptom onset and antiviral therapy dates, only eight 
      (17%) received neuraminidase inhibitors within 48 hours of symptom onset. This 
      report supports previous recommendations that vaccination is important to prevent 
      influenza virus infections that can result in ICU admission or death, 
      particularly in high-risk populations, and that empiric antiviral treatment 
      should be promptly initiated when influenza virus infection is suspected in 
      hospitalized patients, despite negative results from rapid diagnostic tests.
FAU - Ayscue, Patrick
AU  - Ayscue P
FAU - Murray, Erin
AU  - Murray E
FAU - Uyeki, Timothy
AU  - Uyeki T
FAU - Zipprich, Jennifer
AU  - Zipprich J
FAU - Harriman, Kathleen
AU  - Harriman K
FAU - Salibay, Catheryn
AU  - Salibay C
FAU - Kang, Monica
AU  - Kang M
FAU - Luu, Annie
AU  - Luu A
FAU - Glenn-Finer, Rose
AU  - Glenn-Finer R
FAU - Watt, James
AU  - Watt J
FAU - Glaser, Carol
AU  - Glaser C
FAU - Louie, Janice
AU  - Louie J
CN  - Centers for Disease Control and Prevention (CDC)
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MMWR Morb Mortal Wkly Rep
JT  - MMWR. Morbidity and mortality weekly report
JID - 7802429
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - California/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Influenza, Human/*mortality/*therapy
MH  - Intensive Care Units/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Patient Admission/*statistics & numerical data
MH  - *Population Surveillance
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC4584758
EDAT- 2014/02/21 06:00
MHDA- 2014/04/04 06:00
PMCR- 2014/02/21
CRDT- 2014/02/21 06:00
PHST- 2014/02/21 06:00 [entrez]
PHST- 2014/02/21 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
PHST- 2014/02/21 00:00 [pmc-release]
AID - mm6307a2 [pii]
AID - 143-147 [pii]
PST - ppublish
SO  - MMWR Morb Mortal Wkly Rep. 2014 Feb 21;63(7):143-7.