PMID- 24554791 OWN - NLM STAT- MEDLINE DCOM- 20160504 LR - 20220330 IS - 1468-2834 (Electronic) IS - 0002-0729 (Linking) VI - 43 IP - 5 DP - 2014 Sep TI - The effects of multimodal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial. PG - 623-9 LID - 10.1093/ageing/afu010 [doi] AB - OBJECTIVE: to test the effect of a 16-week multimodal exercise program on neurocognitive and physical functioning and brain-derived neurotrophic factor (BDNF). DESIGN: a single-blinded, parallel-group randomised controlled trial. SETTINGS: university campus and community-based halls. SUBJECTS: forty-nine women aged 65 to 75 years, with no cognitive impairment and not undertaking more than 1 h of formal exercise training per week. METHODS: the intervention group attended a 60-min multimodal class twice each week which included cardiovascular, strength and motor fitness training. The primary outcome was neurocognitive functioning and secondary outcomes were physical functioning and plasma levels of BDNF. RESULTS: twenty-five participants were randomised to the intervention group and 24 to the control group. One control participant withdrew before follow-up data collection. The intervention group performed significantly better than the control group at follow-up (when controlled for baseline) in the Trail Making test A and B, the California Older Adult Stroop test (Word, Interference and Total scores), Controlled Oral Word Association test and the Timed Up-and-Go test, Six-Minute Walk test, One-Legged Stance test and plasma BDNF. CONCLUSION: this multimodal exercise program resulted in neurocognitive and physical performance improvements and increased levels of plasma BDNF, in older women, when compared with controls. This RCT provides evidence that a multimodal exercise intervention can achieve larger effect sizes than those generally resulting from single modality interventions. Increases in BDNF levels imply neurogenesis may be a component of the mechanism underpinning the cognitive improvements associated with multimodal exercise. TRIAL REGISTRATION: Australian and New Zealand Clinical Trial Registration Number: ANZCTR12612000451808. CI - (c) The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Vaughan, Sue AU - Vaughan S AD - Griffith University, School of Rehabilitation Sciences, G02 Gold Coast Campus, Gold Coast, QLD 4222, Australia. FAU - Wallis, Marianne AU - Wallis M AD - University of the Sunshine Coast, School of Nursing and Midwifery, Sunshine Coast, QLD, Australia Griffith University, Research Centre for Health Practice Innovation, Gold Coast, QLD, Australia. FAU - Polit, Denise AU - Polit D AD - Griffith University, Research Centre for Health Practice Innovation, Gold Coast, QLD, Australia. FAU - Steele, Mike AU - Steele M AD - Griffith University, Graduate Research School, Gold Coast, QLD, Australia Mathematical and Computing Sciences, Faculty of Science, Universiti Brunei Darussalam, Darussalam, Brunei. FAU - Shum, David AU - Shum D AD - Griffith University, Griffith Health Institute, Gold Coast, QLD, Australia. FAU - Morris, Norman AU - Morris N AD - Griffith University, School of Rehabilitation Sciences, G02 Gold Coast Campus, Gold Coast, QLD 4222, Australia. LA - eng SI - ANZCTR/ANZCTR12612000451808 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140218 PL - England TA - Age Ageing JT - Age and ageing JID - 0375655 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Age Factors MH - Aged MH - *Aging/metabolism/psychology MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - *Cognition MH - Exercise Test MH - *Exercise Therapy MH - Exercise Tolerance MH - Female MH - *Health Status MH - Humans MH - Motor Activity MH - Muscle Strength MH - Neuropsychological Tests MH - Predictive Value of Tests MH - Queensland MH - Sex Factors MH - Single-Blind Method MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - aged OT - brain-derived neurotrophic factor OT - cognition OT - executive function OT - exercise OT - multimodal exercise OT - older people EDAT- 2014/02/21 06:00 MHDA- 2016/05/05 06:00 CRDT- 2014/02/21 06:00 PHST- 2014/02/21 06:00 [entrez] PHST- 2014/02/21 06:00 [pubmed] PHST- 2016/05/05 06:00 [medline] AID - afu010 [pii] AID - 10.1093/ageing/afu010 [doi] PST - ppublish SO - Age Ageing. 2014 Sep;43(5):623-9. doi: 10.1093/ageing/afu010. Epub 2014 Feb 18.