PMID- 24554876
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 0972-124X (Print)
IS  - 0975-1580 (Electronic)
IS  - 0972-124X (Linking)
VI  - 17
IP  - 6
DP  - 2013 Nov
TI  - Redefining the role of dendritic cells in periodontics.
PG  - 700-5
LID - 10.4103/0972-124X.124467 [doi]
AB  - A properly functioning adaptive immune system signifies the best features of 
      life. It is diverse beyond compare, tolerant without fail, and capable of 
      behaving appropriately with a myriad of infections and other challenges. 
      Dendritic cells (DCs) are required to explain how this remarkable system is 
      energized and directed. DCs consist of a family of antigen presenting cells, 
      which are bone-marrow-derived cells that patrol all tissues of the body with the 
      possible exceptions of the brain and testes. DCs function to capture bacteria and 
      other pathogens for processing and presentation to T cells in the secondary 
      lymphoid organs. They serve as an essential link between innate and adaptive 
      immune systems and induce both primary and secondary immune responses. As a 
      result of progress worldwide, there is now evidence of a central role for 
      dendritic cells in initiating antigen-specific immunity and tolerance. This 
      review addresses the origins and migration of DCs to target sites, their basic 
      biology and plasticity in playing a key role in periodontal diseases, and 
      finally, selected strategies being pursued to harness its ability to prevent 
      periodontal diseases.
FAU - Venkatesan, Gomathinayagam
AU  - Venkatesan G
AD  - Department of Periodontology, Manipal College of Dental Sciences, Manipal 
      University, Light House Hill Road, Mangalore, Karnataka, India.
FAU - Uppoor, Ashita
AU  - Uppoor A
AD  - Department of Periodontology, Manipal College of Dental Sciences, Manipal 
      University, Light House Hill Road, Mangalore, Karnataka, India.
FAU - Naik, Dilip G
AU  - Naik DG
AD  - Department of Periodontology, Manipal College of Dental Sciences, Manipal 
      University, Light House Hill Road, Mangalore, Karnataka, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - J Indian Soc Periodontol
JT  - Journal of Indian Society of Periodontology
JID - 101499342
PMC - PMC3917196
OTO - NOTNLM
OT  - Dendritic cells
OT  - osteoimmunology
OT  - periodontitis
OT  - vaccine
COIS- Conflict of Interest: None declared.
EDAT- 2014/02/21 06:00
MHDA- 2014/02/21 06:01
PMCR- 2013/11/01
CRDT- 2014/02/21 06:00
PHST- 2012/11/17 00:00 [received]
PHST- 2013/09/21 00:00 [accepted]
PHST- 2014/02/21 06:00 [entrez]
PHST- 2014/02/21 06:00 [pubmed]
PHST- 2014/02/21 06:01 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - JISP-17-700 [pii]
AID - 10.4103/0972-124X.124467 [doi]
PST - ppublish
SO  - J Indian Soc Periodontol. 2013 Nov;17(6):700-5. doi: 10.4103/0972-124X.124467.