PMID- 24556405
OWN - NLM
STAT- MEDLINE
DCOM- 20140811
LR  - 20230120
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 26
DP  - 2014 Feb
TI  - Organization of the mouse and human DC network.
PG  - 90-9
LID - S0952-7915(13)00212-4 [pii]
LID - 10.1016/j.coi.2013.11.002 [doi]
AB  - Dendritic cells (DCs) are the most potent antigen sensing and presenting cells in 
      the body and are able to both initiate and fine-tune complex immune responses on 
      a multitude of levels. In this review, we outline recent advances in our 
      understanding of the organization of the DC network in mice and humans, the 
      functional specialization of the DC subsets that compose these networks, and how 
      this has enabled us to begin to elucidate cross-species parallels. Understanding 
      the inter-relationships between DC populations in both man and mouse will 
      ultimately allow us to exploit our knowledge of DC biology for effective 
      therapeutic strategies.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Schlitzer, Andreas
AU  - Schlitzer A
AD  - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research 
      (A*STAR), 138648 Singapore.
FAU - Ginhoux, Florent
AU  - Ginhoux F
AD  - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research 
      (A*STAR), 138648 Singapore. Electronic address: 
      Florent_ginhoux@immunol.a-star.edu.sg.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131203
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (Antigens, Surface)
RN  - 0 (CD11b Antigen)
RN  - 0 (CD1C protein, human)
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8alpha antigen)
RN  - 0 (Glycoproteins)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (THBD protein, human)
RN  - 0 (Thrombomodulin)
RN  - 0 (alpha E integrins)
SB  - IM
MH  - Animals
MH  - Antigens, CD/biosynthesis
MH  - Antigens, CD1/biosynthesis
MH  - Antigens, Surface/biosynthesis
MH  - CD11b Antigen/biosynthesis
MH  - CD8 Antigens/biosynthesis
MH  - Cell Polarity/immunology
MH  - Cross-Priming/immunology
MH  - Dendritic Cells/cytology/*immunology/*metabolism
MH  - Glycoproteins/biosynthesis
MH  - Humans
MH  - Immunity, Cellular
MH  - Inflammation/immunology/pathology
MH  - Integrin alpha Chains/biosynthesis
MH  - Mice
MH  - Th17 Cells/immunology
MH  - Thrombomodulin
EDAT- 2014/02/22 06:00
MHDA- 2014/08/12 06:00
CRDT- 2014/02/22 06:00
PHST- 2013/09/23 00:00 [received]
PHST- 2013/11/02 00:00 [revised]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2014/02/22 06:00 [entrez]
PHST- 2014/02/22 06:00 [pubmed]
PHST- 2014/08/12 06:00 [medline]
AID - S0952-7915(13)00212-4 [pii]
AID - 10.1016/j.coi.2013.11.002 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2014 Feb;26:90-9. doi: 10.1016/j.coi.2013.11.002. Epub 2013 
      Dec 3.