PMID- 24557678
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140221
LR  - 20211021
IS  - 1673-7342 (Print)
IS  - 1673-7342 (Linking)
VI  - 1
IP  - 2
DP  - 2007 May
TI  - Effects of intracerebroventricular NMDA and non-NMDA receptor agonists or 
      antagonists on general anesthesia of propofol in mice.
PG  - 207-10
LID - 10.1007/s11684-007-0039-x [doi]
AB  - The effects of intracerebroventricular (icv) agonists and antagonists of 
      N-methyl-D-aspartate (NMDA) and 
      alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the 
      general anesthesia of propofol were studied. A total of 144 Kunming mice, male 
      and female with body mass of (22+/-3) g, were used. Part One of the Experiment: a 
      total of 104 Kunming mice, male and female, were randomly divided into 13 groups. 
      Intracerebroventricular artificial cerebral fluid (aCSF) or different doses of 
      NMDA, AMPA, MK-801 or NBQX was injected immediately after intravenously 
      administered propofol 25 mg/kg and the recovery time following the loss of 
      righting reflex (LORR) was recorded. Part Two of the Experiment: a total of 40 
      Kunming female mice were divided randomly into 5 groups and injected with icv 
      aCSF or NMDA, AMPA, MK-801 or NBQX after intraperitoneally administered propofol 
      50 mg/kg. The pain threshold of the mice was then investigated by hot-plate test 
      (HPPT). NMDA (0.05 or 0.075mug, icv) or AMPA (0.05 mug, icv) exhibited no effects 
      on the LORR, but NMDA (0.1 mug, icv) or AMPA (0.075 or 0.1 mug, icv) prolonged the 
      LORR significantly compared with the aCSF group (P<0.05, P<0.01). The LORR of the 
      2 mug MK-801 group had no changes, while those of the 4 or 8 mug MK-801 groups were 
      prolonged significantly. The LORR of the 0.5, 2 or 4 mug NBQX groups were all 
      prolonged significantly. NMDA 0.05 mug or AMPA 0.05 mug decreased the pain 
      threshold slightly but did not differ in effect compared with the aCSF group; 2 
      mug MK-801 or 0.5 mug NBQX both increased the pain threshold significantly. Our 
      results indicate that propofol produces general anesthesia partly through an 
      interaction with brain NMDA and AMPA receptors in mice.
FAU - Xu, Aijun
AU  - Xu A
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Duan, Shiming
AU  - Duan S
FAU - Tian, Yuke
AU  - Tian Y
LA  - eng
PT  - Journal Article
DEP - 20070501
PL  - China
TA  - Front Med China
JT  - Frontiers of medicine in China
JID - 101392716
EDAT- 2007/05/01 00:00
MHDA- 2007/05/01 00:01
CRDT- 2014/02/22 06:00
PHST- 2007/01/24 00:00 [received]
PHST- 2007/02/28 00:00 [accepted]
PHST- 2014/02/22 06:00 [entrez]
PHST- 2007/05/01 00:00 [pubmed]
PHST- 2007/05/01 00:01 [medline]
AID - 10.1007/s11684-007-0039-x [doi]
PST - ppublish
SO  - Front Med China. 2007 May;1(2):207-10. doi: 10.1007/s11684-007-0039-x. Epub 2007 
      May 1.