PMID- 24558837
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 31
IP  - 11
DP  - 2013 Nov
TI  - [Determination of triclosan and triclocarban in human nails by solid-phase 
      extraction and ultra performance liquid chromatography-tandem mass spectrometry].
PG  - 1040-5
AB  - An analytical method was developed to simultaneously detect triclosan (TCS) and 
      triclocarban (TCC) in human nails using solid phase extraction (SPE) with ultra 
      performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Nail 
      clippings were digested by sodium hydroxide, and then concentrated and purified 
      with C18 cartridges. Chromatographic separation was performed on a Waters ACQUITY 
      UPLC HSS T3 column (100 mm x 2.1 mm, 1.8 microm) with gradient elution using 
      methanol and water at a flow rate of 0.3 mL/min. The target compounds were 
      determined by triple quadrupole mass spectrometer operated in the negative ion 
      mode and quantified by isotopic-dilution technique. The satisfactory linearities 
      (r2 = 0.999) was obtained over the ranges of 0.5-500.0 microg/kg for TCS and 
      0.1-100.0 microg/kg for TCC, with the limits of quantification (LOQs) of 2.0 
      microg/kg for TCS and 0. 2 microg/kg for TCC. The average recoveries of the two 
      target compounds (spiked at three concentration levels) ranged from 95.9% to 
      110.2%, with the relative standard deviations (RSDs) between 0.6% and 9.7% (n = 
      6). This method can be applied in rapid detection of target contaminants in nails 
      due to its high sensitivity, high recovery and good reproducibility. Sixty 
      collected human nail samples were analyzed by means of the developed method. TCS 
      and TCC were detected in all samples with content ranges of < LOQ-760.7 microg/kg 
      and 4.1-1926.5 microg/kg, respectively.
FAU - Shi, Ying
AU  - Shi Y
AD  - School of Public Health, Capital Medical University, Beijing 100069, China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - School of Public Health, Capital Medical University, Beijing 100069, China.
FAU - Lu, Libin
AU  - Lu L
AD  - School of Public Health, Capital Medical University, Beijing 100069, China.
FAU - Shao, Bing
AU  - Shao B
AD  - School of Public Health, Capital Medical University, Beijing 100069, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Carbanilides)
RN  - 4NM5039Y5X (Triclosan)
RN  - BGG1Y1ED0Y (triclocarban)
SB  - IM
MH  - Carbanilides/*analysis
MH  - Chromatography, High Pressure Liquid
MH  - Humans
MH  - Nails/*chemistry
MH  - Reproducibility of Results
MH  - Solid Phase Extraction
MH  - *Tandem Mass Spectrometry
MH  - Triclosan/*analysis
EDAT- 2014/02/25 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/02/25 06:00
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3724/sp.j.1123.2013.05032 [doi]
PST - ppublish
SO  - Se Pu. 2013 Nov;31(11):1040-5. doi: 10.3724/sp.j.1123.2013.05032.