PMID- 24558953
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20240321
IS  - 2325-6621 (Electronic)
IS  - 2329-6933 (Print)
IS  - 2325-6621 (Linking)
VI  - 11
IP  - 3
DP  - 2014 Mar
TI  - Quantitative computed tomography measures of pectoralis muscle area and disease 
      severity in chronic obstructive pulmonary disease. A cross-sectional study.
PG  - 326-34
LID - 10.1513/AnnalsATS.201307-229OC [doi]
AB  - RATIONALE: Muscle wasting in chronic obstructive pulmonary disease (COPD) is 
      associated with a poor prognosis and is not readily assessed by measures of body 
      mass index (BMI). BMI does not discriminate between relative proportions of 
      adipose tissue and lean muscle and may be insensitive to early pathologic changes 
      in body composition. Computed tomography (CT)-based assessments of the pectoralis 
      muscles may provide insight into the clinical significance of skeletal muscles in 
      smokers. OBJECTIVES: We hypothesized that objective assessment of the pectoralis 
      muscle area on chest CT scans provides information that is clinically relevant 
      and independent of BMI. METHODS: Data from the ECLIPSE (Evaluation of COPD 
      Longitudinally to Identify Predictive Surrogate Endpoints) Study (n = 73) were 
      used to assess the relationship between pectoralis muscle area and fat-free mass. 
      We then used data in a subset (n = 966) of a larger cohort, the COPDGene (COPD 
      Genetic Epidemiology) Study, to explore the relationship between pectoralis 
      muscle area and COPD-related traits. MEASUREMENTS AND MAIN RESULTS: We first 
      investigated the correlation between pectoralis muscle area and fat-free mass, 
      using data from a subset of participants in the ECLIPSE Study. We then further 
      investigated pectoralis muscle area in COPDGene Study participants and found that 
      higher pectoralis muscle area values were associated with greater height, male 
      sex, and younger age. On subsequent clinical correlation, compared with BMI, 
      pectoralis muscle area was more significantly associated with COPD-related 
      traits, including spirometric measures, dyspnea, and 6-minute-walk distance 
      (6MWD). For example, on average, each 10-cm(2) increase in pectoralis muscle area 
      was associated with a 0.8-unit decrease in the BODE (Body mass index, 
      Obstruction, Dyspnea, Exercise) index (95% confidence interval, -1.0 to -0.6; P < 
      0.001). Furthermore, statistically significant associations between pectoralis 
      muscle area and COPD-related traits remained even after adjustment for BMI. 
      CONCLUSIONS: CT-derived pectoralis muscle area provides relevant indices of COPD 
      morbidity that may be more predictive of important COPD-related traits than BMI. 
      However, the relationship with clinically relevant outcomes such as 
      hospitalization and death requires additional investigation. Pectoralis muscle 
      area is a convenient measure that can be collected in the clinical setting in 
      addition to BMI.
FAU - McDonald, Merry-Lynn N
AU  - McDonald ML
AD  - 1 Channing Division of Network Medicine, Harvard Medical School, Boston, 
      Massachusetts.
FAU - Diaz, Alejandro A
AU  - Diaz AA
FAU - Ross, James C
AU  - Ross JC
FAU - San Jose Estepar, Raul
AU  - San Jose Estepar R
FAU - Zhou, Linfu
AU  - Zhou L
FAU - Regan, Elizabeth A
AU  - Regan EA
FAU - Eckbo, Eric
AU  - Eckbo E
FAU - Muralidhar, Nina
AU  - Muralidhar N
FAU - Come, Carolyn E
AU  - Come CE
FAU - Cho, Michael H
AU  - Cho MH
FAU - Hersh, Craig P
AU  - Hersh CP
FAU - Lange, Christoph
AU  - Lange C
FAU - Wouters, Emiel
AU  - Wouters E
FAU - Casaburi, Richard H
AU  - Casaburi RH
FAU - Coxson, Harvey O
AU  - Coxson HO
FAU - Macnee, William
AU  - Macnee W
FAU - Rennard, Stephen I
AU  - Rennard SI
FAU - Lomas, David A
AU  - Lomas DA
FAU - Agusti, Alvar
AU  - Agusti A
FAU - Celli, Bartolome R
AU  - Celli BR
FAU - Black-Shinn, Jennifer L
AU  - Black-Shinn JL
FAU - Kinney, Greg L
AU  - Kinney GL
FAU - Lutz, Sharon M
AU  - Lutz SM
FAU - Hokanson, John E
AU  - Hokanson JE
FAU - Silverman, Edwin K
AU  - Silverman EK
FAU - Washko, George R
AU  - Washko GR
LA  - eng
GR  - R01 HL122464/HL/NHLBI NIH HHS/United States
GR  - K23 HL114735/HL/NHLBI NIH HHS/United States
GR  - T32 ES007142/ES/NIEHS NIH HHS/United States
GR  - U01 HL089897/HL/NHLBI NIH HHS/United States
GR  - R01 HL116931/HL/NHLBI NIH HHS/United States
GR  - K01 HL118714/HL/NHLBI NIH HHS/United States
GR  - U01 HL089856/HL/NHLBI NIH HHS/United States
GR  - G0901786/MRC_/Medical Research Council/United Kingdom
GR  - K25 HL104085/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ann Am Thorac Soc
JT  - Annals of the American Thoracic Society
JID - 101600811
SB  - IM
MH  - Aged
MH  - Body Composition
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pectoralis Muscles/*diagnostic imaging/*pathology
MH  - Predictive Value of Tests
MH  - Pulmonary Disease, Chronic Obstructive/complications/*diagnostic 
      imaging/*physiopathology
MH  - Respiratory Function Tests
MH  - Severity of Illness Index
MH  - Smoking
MH  - *Tomography, X-Ray Computed
PMC - PMC4028743
EDAT- 2014/02/25 06:00
MHDA- 2014/12/17 06:00
PMCR- 2015/03/01
CRDT- 2014/02/25 06:00
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - 10.1513/AnnalsATS.201307-229OC [doi]
PST - ppublish
SO  - Ann Am Thorac Soc. 2014 Mar;11(3):326-34. doi: 10.1513/AnnalsATS.201307-229OC.