PMID- 24559259
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140307
LR  - 20211021
IS  - 1869-5760 (Print)
IS  - 1869-5760 (Electronic)
IS  - 1869-5760 (Linking)
VI  - 4
IP  - 1
DP  - 2014 Feb 22
TI  - Changes of fundus autofluorescence and spectral-domain optical coherence 
      tomographic findings after treatment of primary intraocular lymphoma.
PG  - 7
LID - 10.1186/1869-5760-4-7 [doi]
AB  - BACKGROUND: We report the fundus autofluorescence (FAF), spectral-domain optical 
      coherence tomographic (SD-OCT), microperimetric, and multifocal 
      electroretinographic (mfERG) findings before, during, and after successful 
      treatment of a primary intraocular lymphoma (PIOL). FINDINGS: A 57-year-old man 
      had biopsy-proven PIOL in his left eye, and he was treated with intravitreal 
      methotrexate injections for 8 months. Before treatment, fundus examination 
      disclosed many small, yellow lesions with distinct boundaries in the posterior 
      fundus which became atrophic 9 months after the initial treatment. FAF showed a 
      pattern of granular hypoautofluorescence and hyperautofluorescence before the 
      treatments and patchy hypoautofluorescence corresponding to retinal pigment 
      epithelial (RPE) atrophy after the treatments. SD-OCT showed increased nodularity 
      at the level of and above the RPE, a separation of Bruch membrane from the RPE, 
      partial damage of the RPE, disruption of the photoreceptor inner segment/outer 
      segment (IS/OS) junction, multiple hyperreflective signals in the inner retina, 
      foveal thinning, and parafoveal thickening. After treatment, the hyperreflective 
      infiltrations in the inner retina were markedly decreased, and the RPE and IS/OS 
      junction were restored. The foveal thinning and parafoveal thickening resolved, 
      and the central choroidal thickness decreased. During the follow-up, the mfERGs 
      remained decreased. In contrast, microperimetry showed a partial improvement of 
      the retinal sensitivity. CONCLUSION: FAF and SD-OCT are useful noninvasive 
      methods to evaluate the retinal and choroidal changes before and after treatment 
      of PIOL. Our results suggest that visual recovery after successful treatment may 
      be limited once macula is infiltrated.
FAU - Egawa, Mariko
AU  - Egawa M
AD  - Department of Ophthalmology, Institute of Health Biosciences, The University of 
      Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. 
      egawa.m@tokushima-u.ac.jp.
FAU - Mitamura, Yoshinori
AU  - Mitamura Y
FAU - Hayashi, Yuki
AU  - Hayashi Y
FAU - Semba, Kentaro
AU  - Semba K
FAU - Naito, Takeshi
AU  - Naito T
LA  - eng
PT  - Journal Article
DEP - 20140222
PL  - Germany
TA  - J Ophthalmic Inflamm Infect
JT  - Journal of ophthalmic inflammation and infection
JID - 101553216
PMC - PMC3944943
EDAT- 2014/02/25 06:00
MHDA- 2014/02/25 06:01
PMCR- 2014/01/01
CRDT- 2014/02/25 06:00
PHST- 2014/01/21 00:00 [received]
PHST- 2014/02/13 00:00 [accepted]
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2014/02/25 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 1869-5760-4-7 [pii]
AID - 10.1186/1869-5760-4-7 [doi]
PST - epublish
SO  - J Ophthalmic Inflamm Infect. 2014 Feb 22;4(1):7. doi: 10.1186/1869-5760-4-7.