PMID- 24560611
OWN - NLM
STAT- MEDLINE
DCOM- 20141030
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 216
IP  - 2
DP  - 2014 May 15
TI  - High prevalence of Human Herpesvirus 8 in schizophrenic patients.
PG  - 192-7
LID - S0165-1781(13)00828-7 [pii]
LID - 10.1016/j.psychres.2013.12.035 [doi]
AB  - Many studies have reported an association between Herpes family viruses and an 
      increased risk of schizophrenia, but the role of Human Herpesvirus 8 (HHV8) has 
      never been investigated. This study aimed to assess HHV8 prevalence in 
      schizophrenic patients as well as the possible association between HHV8 infection 
      and schizophrenia clinical features. We consecutively enrolled 108 patients 
      meeting fourth edition of Diagnostic and Statistical Manual of Mental Disorders 
      (DSM-IV) criteria of schizophrenia and 108 age and sex matched controls. Data 
      about a number of demographic characteristics and potential HHV8 risk factors of 
      infection were collected. Standardized psychopathology measures, disease severity 
      and functioning level were obtained using Positive and Negative Syndrome Scale 
      (PANSS), Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of 
      Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), 
      Clinical Global Impressions (CGI) and Global Assessment of functioning (GAF). The 
      presence of anti-HHV8 antibodies was analyzed using an indirect 
      immunofluorescence assay. A higher prevalence of HHV8 infection in schizophrenic 
      patients than in controls was found. Marital status, having children, sexual 
      behavior and risk factors of blood transmission were not associated with HHV8 
      prevalence. However, among schizophrenic patients, HHV8 prevalence was statically 
      associated with positive symptoms. To our knowledge, this would be the first 
      report of a possible role of HHV8 in the pathogenesis of schizophrenia. To prove 
      this hypothesis, further investigation of HHV8 in schizophrenia with larger 
      samples is needed.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Hannachi, Neila
AU  - Hannachi N
AD  - Department of Microbiology and Immunology, Farhat Hached University Hospital, Ibn 
      El Jazzar Street, Sousse 4000, Tunisia; Research Unit (UR02SP13), Farhat Hached 
      University Hospital, Ibn El Jazzar Street, Sousse 4000, Tunisia.
FAU - El Kissi, Yousri
AU  - El Kissi Y
AD  - Department of Psychiatry, Farhat Hached University Hospital, Ibn El Jazzar 
      Street, Sousse 4000, Tunisia. Electronic address: yousri.elkissi@rns.tn.
FAU - Samoud, Samar
AU  - Samoud S
AD  - Department of Microbiology and Immunology, Farhat Hached University Hospital, Ibn 
      El Jazzar Street, Sousse 4000, Tunisia; Research Unit (UR02SP13), Farhat Hached 
      University Hospital, Ibn El Jazzar Street, Sousse 4000, Tunisia.
FAU - Nakhli, Jaafar
AU  - Nakhli J
AD  - Department of Psychiatry, Farhat Hached University Hospital, Ibn El Jazzar 
      Street, Sousse 4000, Tunisia.
FAU - Letaief, Leila
AU  - Letaief L
AD  - Department of Psychiatry, Farhat Hached University Hospital, Ibn El Jazzar 
      Street, Sousse 4000, Tunisia.
FAU - Gaabout, Samia
AU  - Gaabout S
AD  - Department of Psychiatry, Farhat Hached University Hospital, Ibn El Jazzar 
      Street, Sousse 4000, Tunisia.
FAU - Ali, Bechir Ben Hadj
AU  - Ali BB
AD  - Department of Psychiatry, Farhat Hached University Hospital, Ibn El Jazzar 
      Street, Sousse 4000, Tunisia.
FAU - Boukadida, Jalel
AU  - Boukadida J
AD  - Department of Microbiology and Immunology, Farhat Hached University Hospital, Ibn 
      El Jazzar Street, Sousse 4000, Tunisia; Research Unit (UR02SP13), Farhat Hached 
      University Hospital, Ibn El Jazzar Street, Sousse 4000, Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20131231
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Herpesviridae Infections/*complications/diagnosis/epidemiology/*virology
MH  - Herpesvirus 8, Human/*isolation & purification/pathogenicity
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Prevalence
MH  - Risk Factors
MH  - Schizophrenia/*complications/epidemiology/*virology
MH  - Sexual Behavior
OTO - NOTNLM
OT  - Epidemiology
OT  - Human Herpesvirus 8
OT  - Positive symptoms
OT  - Schizophrenia
EDAT- 2014/02/25 06:00
MHDA- 2014/10/31 06:00
CRDT- 2014/02/25 06:00
PHST- 2012/10/25 00:00 [received]
PHST- 2013/12/19 00:00 [revised]
PHST- 2013/12/21 00:00 [accepted]
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2014/10/31 06:00 [medline]
AID - S0165-1781(13)00828-7 [pii]
AID - 10.1016/j.psychres.2013.12.035 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 May 15;216(2):192-7. doi: 10.1016/j.psychres.2013.12.035. 
      Epub 2013 Dec 31.