PMID- 24560614
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20150728
IS  - 1096-0937 (Electronic)
IS  - 1087-1845 (Linking)
VI  - 81
DP  - 2015 Aug
TI  - Transcriptomic reprogramming of genus Paracoccidioides in dimorphism and host 
      niches.
PG  - 98-109
LID - S1087-1845(14)00017-6 [pii]
LID - 10.1016/j.fgb.2014.01.008 [doi]
AB  - The thermodimorphic fungi Paracoccidioides brasiliensis and Paracoccidioides 
      lutzii are the etiologic agents of Paracoccidioidomycosis (PCM), the most 
      important endemic systemic mycosis in Latin America. Paracoccidioides grows as 
      saprophytic mycelia that produce infective conidia propagules, which are inhaled 
      into the lungs where the fungus converts to the pathogenic yeast form. From the 
      lungs, Paracoccidioides may disseminate through blood and lymphatics to several 
      other organs and tissues. During the last decade we have witnessed the generation 
      of a large amount of transcriptomic data regarding the events leading to the 
      morphological transition and host niche adaptation. In this review we summarize 
      those findings and discuss the consequence of gene expression plasticity in the 
      persistence and survival of this pathogen. In addition, we discuss the future 
      trends on the host-pathogen studies and how new molecular strategies, such as 
      RNA-seq, dual RNA-seq and Chip-Seq can be powerful tools to improve our 
      understanding on the pathobiology of this systemic mycosis in Latin America.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Tavares, Aldo Henrique
AU  - Tavares AH
AD  - Lab. de Imunologia Aplicada, CEL/IB, Universidade de Brasilia, Brasilia-DF, 
      Brazil; Faculdade de Ceilandia, FCE, Universidade de Brasilia, Brasilia - DF, 
      Brazil.
FAU - Fernandes, Larissa
AU  - Fernandes L
AD  - Lab. de Biologia Molecular, CEL/IB, Universidade de Brasilia, Brasilia-DF, 
      Brazil; Faculdade de Ceilandia, FCE, Universidade de Brasilia, Brasilia - DF, 
      Brazil.
FAU - Bocca, Anamelia Lorenzetti
AU  - Bocca AL
AD  - Lab. de Imunologia Aplicada, CEL/IB, Universidade de Brasilia, Brasilia-DF, 
      Brazil.
FAU - Silva-Pereira, Ildinete
AU  - Silva-Pereira I
AD  - Lab. de Biologia Molecular, CEL/IB, Universidade de Brasilia, Brasilia-DF, 
      Brazil.
FAU - Felipe, Maria Sueli
AU  - Felipe MS
AD  - Lab. de Biologia Molecular, CEL/IB, Universidade de Brasilia, Brasilia-DF, 
      Brazil; Ciencias Genomicas e Biotecnologia, Universidade Catolica de Brasilia - 
      DF, Brazil. Electronic address: msueli@unb.br.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140218
PL  - United States
TA  - Fungal Genet Biol
JT  - Fungal genetics and biology : FG & B
JID - 9607601
SB  - IM
MH  - Animals
MH  - *Gene Expression Profiling
MH  - *Gene Expression Regulation, Fungal
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Paracoccidioides/cytology/*genetics/*growth & development
MH  - Virulence
OTO - NOTNLM
OT  - Dimorphism
OT  - Host-pathogen interaction
OT  - Paracoccidioides
OT  - Transcriptome profiling
EDAT- 2014/02/25 06:00
MHDA- 2016/04/20 06:00
CRDT- 2014/02/25 06:00
PHST- 2013/09/02 00:00 [received]
PHST- 2014/01/27 00:00 [revised]
PHST- 2014/01/31 00:00 [accepted]
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - S1087-1845(14)00017-6 [pii]
AID - 10.1016/j.fgb.2014.01.008 [doi]
PST - ppublish
SO  - Fungal Genet Biol. 2015 Aug;81:98-109. doi: 10.1016/j.fgb.2014.01.008. Epub 2014 
      Feb 18.